| Thrombocytopenic conditions-autoimmunity and hypercoagulability: commonalities and differences in ITP, TTP, HIT, and APS. | |
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MedLine Citation:
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PMID: 16247748 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Immune thrombocytopenia purpura (ITP), thrombotic thrombocytopenia purpura (TTP), heparin-induced thrombocytopenia (HIT), and antiphospholipid syndrome (APS) are clinical conditions associated with significant morbidity and mortality. These well-defined clinical syndromes have in common several properties: (1) their pathogenesis is immune mediated, specifically by autoantibodies; (2) thrombocytopenia is a hallmark in these four conditions; (3) except for the case of ITP, platelet and endothelial cell activation occurs in TTP, HIT, and APS, resulting in a prothrombotic state and an increased risk of thrombosis. Although these four immune-mediated syndromes are well-defined diseases, several case reports and studies have documented the association of two diseases in the same patient, illustrating the concept of the kaleidoscope of autoimmunity. |
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Authors:
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Martine Szyper Kravitz; Yehuda Shoenfeld |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: American journal of hematology Volume: 80 ISSN: 0361-8609 ISO Abbreviation: Am. J. Hematol. Publication Date: 2005 Nov |
Date Detail:
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Created Date: 2005-10-31 Completed Date: 2006-01-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7610369 Medline TA: Am J Hematol Country: United States |
Other Details:
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Languages: eng Pagination: 232-42 Citation Subset: IM |
Affiliation:
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Center for Autoimmune Diseases and Department of Medicine B, Chaim Sheba Medical Center Tel-Hashomer, Sackler Faculty of Medicine, Tel Aviv University, Israel. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Autoimmunity* Heparin / adverse effects, immunology Humans Purpura, Thrombocytopenic, Idiopathic / etiology, immunology Purpura, Thrombotic Thrombocytopenic / etiology, immunology Thrombocytopenia / classification, etiology* Thrombophilia / complications* |
| Chemical | |
Reg. No./Substance:
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9005-49-6/Heparin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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