Document Detail

Thrombocytopenia and thromboembolism in pediatric systemic lupus erythematosus.
MedLine Citation:
PMID:  14615743     Owner:  NLM     Status:  MEDLINE    
To define in children with systemic lupus erythematosus (SLE) the incidence, outcome, and association of thrombocytopenia with other SLE manifestations, specifically thromboembolic events (TEs), we retrospectively reviewed 106 pediatric patients with SLE diagnosed between 1992 and 2001. Thrombocytopenia was found in 50%, which was of a moderate or severe degree in 34%. The thrombocytopenia was sustained in 29% of all patients. Twelve patients were diagnosed with autoimmune thrombocytopenic purpura 2 to 69 months before the diagnosis of SLE. Of them, 10 children required treatment, and three patients underwent splenectomy. TEs occurred in 10.4% of the total cohort of 106. Lupus anticoagulant, but not anticardiolipin antibodies and sustained thrombocytopenia, were associated with a higher risk for TEs.
Markus Schmugge; Shoshana Revel-Vilk; Linda Hiraki; Margaret L Rand; Victor S Blanchette; Earl D Silverman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  143     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-11-17     Completed Date:  2004-01-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  666-9     Citation Subset:  AIM; IM    
Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada.
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MeSH Terms
Antibodies / blood,  immunology
Child, Preschool
Lupus Erythematosus, Systemic / epidemiology*,  immunology
Survival Rate
Thrombocytopenia / epidemiology*,  mortality
Thromboembolism / epidemiology*,  mortality
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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