Document Detail

Thrombocytopenia and platelet functional defects in pre-eclampsia: implications for regional anaesthesia.
MedLine Citation:
PMID:  2368888     Owner:  NLM     Status:  MEDLINE    
A prospective, observational study of forty pre-eclamptic patients was conducted to confirm or refute reports of a platelet functional defect superimposed on the consumptive thrombocytopenia of pre-eclampsia. Investigations included a platelet count, in vivo platelet function as assessed by a Duke bleeding time, and in vitro platelet function as assessed by thromboxane B2 and Platelet Factor 3 (PF 3). The overall incidence of thrombocytopenia was 15%. Prolonged bleeding time and slightly decreased availability of PF 3 (evidence of possible platelet dysfunction) was present in 2.5% of patients while 21% had evidence of fibrinolysis with an elevated monoclonal D-dimer. In the assessment of suitability for regional blockade, a platelet count is essential. If the platelet count is between 50 and 100 x 10(9)/l a bleeding time is indicated.
M Schindler; S Gatt; P Isert; D Morgans; A Cheung
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anaesthesia and intensive care     Volume:  18     ISSN:  0310-057X     ISO Abbreviation:  Anaesth Intensive Care     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-08-13     Completed Date:  1990-08-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0342017     Medline TA:  Anaesth Intensive Care     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  169-74     Citation Subset:  IM    
Department of Anaesthesia, Royal Hospital for Women, Paddington, Sydney, New South Wales.
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MeSH Terms
Anesthesia, Conduction*
Anesthesia, Obstetrical*
Blood Coagulation Tests
Blood Platelets / physiology*
Fibrin Fibrinogen Degradation Products / analysis
Hemoglobins / analysis
Platelet Count
Pre-Eclampsia / blood*
Prospective Studies
Thrombocytopenia / blood*,  epidemiology
Uric Acid / blood
Reg. No./Substance:
0/Fibrin Fibrinogen Degradation Products; 0/Hemoglobins; 69-93-2/Uric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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