Document Detail


Thrombocytopenia in preeclampsia and eclampsia.
MedLine Citation:
PMID:  6813969     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. The lack of a general agreement on the definition of PE makes the interpretation of laboratory findings in different series of these patients difficult. 2. Thrombocytopenia is the most common hemostatic abnormality in patients with PE and is caused by platelet consumption. 3. There is little concrete evidence that thrombin mediates the thrombocytopenia in most of these patients. 4. Immune mechanisms or severe vasospasm with resultant endothelial damage may contribute to the thrombocytopenia in some patients.
Authors:
B Gibson; D Hunter; P B Neame; J G Kelton
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Seminars in thrombosis and hemostasis     Volume:  8     ISSN:  0094-6176     ISO Abbreviation:  Semin. Thromb. Hemost.     Publication Date:  1982 Jul 
Date Detail:
Created Date:  1982-12-16     Completed Date:  1982-12-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0431155     Medline TA:  Semin Thromb Hemost     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  234-47     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Anemia, Hemolytic / blood,  complications
Disseminated Intravascular Coagulation / blood,  complications
Eclampsia / blood*
Epoprostenol / biosynthesis
Factor VIII / biosynthesis
Female
Fibrin / metabolism
Fibrin Fibrinogen Degradation Products / analysis
Fibrinogen / analysis
Fibrinopeptide A / biosynthesis
Humans
Hypertension / complications
Platelet Count
Pre-Eclampsia / blood*,  complications,  pathology
Pregnancy
Pregnancy Complications, Hematologic / blood*
Thrombin / metabolism
Thrombocytopenia / blood*,  complications
Thromboxane A2 / biosynthesis
Chemical
Reg. No./Substance:
0/Fibrin Fibrinogen Degradation Products; 0/fibrinmonomer; 25422-31-5/Fibrinopeptide A; 35121-78-9/Epoprostenol; 57576-52-0/Thromboxane A2; 9001-27-8/Factor VIII; 9001-31-4/Fibrin; 9001-32-5/Fibrinogen; EC 3.4.21.5/Thrombin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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