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Thrombocytopenia at birth in neonates with red cell alloimmune haemolytic disease.
MedLine Citation:
PMID:  21923860     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objective  To evaluate the incidence and severity of and risk factors for thrombocytopenia at birth in neonates with red cell alloimmunization. Study design  All neonates with haemolytic disease of the foetus/newborn (HDFN) due to red cell alloimmunization admitted to our centre between January 2000 and September 2010 were included in this retrospective study. We measured platelet counts at birth and determined the incidence of thrombocytopenia (platelet count < 150 × 10(9) /l) and severe thrombocytopenia (platelet count < 50 × 10(9) /l). Risk factors for thrombocytopenia at birth were evaluated. Results  Thrombocytopenia was present in 26% (94/362) of included neonates with HDFN at birth. Severe thrombocytopenia was found in 6% (20/362) of neonates. Three risk factors were found to be independently associated with thrombocytopenia at birth: treatment with intrauterine red cell transfusion (IUT) (OR 3·32, 95% CI 1·67-6·60, P = 0·001), small for gestational age (SGA) below the 10th percentile (OR 3·32, 95% CI 1·25-8·80, P = 0·016) and lower gestational age at birth (OR 1·22/week, 95% CI 1·02-1·44, P = 0·025). Conclusions  Thrombocytopenia at birth occurs in 26% of neonates with HDFN due to red cell alloimmunization and is independently associated with IUT treatment, SGA and lower gestational age at birth.
Authors:
M E A Rath; V E H J Smits-Wintjens; D Oepkes; E W van Zwet; I L van Kamp; A Brand; F J Walther; E Lopriore
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-16
Journal Detail:
Title:  Vox sanguinis     Volume:  -     ISSN:  1423-0410     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0413606     Medline TA:  Vox Sang     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 The Author(s). Vox Sanguinis © 2011 International Society of Blood Transfusion.
Affiliation:
Division of Neonatology, Department of Pediatrics, Leiden University Medical Center, Leiden, the Netherlands Division of Fetal Medicine, Department of Obstetrics, Leiden University Medical Center, Leiden, the Netherlands Department of Biostatistics, Leiden University Medical Center, Leiden, the Netherlands Sanquin Bloodbank, Southwest Region and Department of Immunohematology and Blood transfusion, Leiden University Medical Center, Leiden, the Netherlands.
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