Document Detail

Thrombocytopenia at baseline is a predictor of inhospital mortality in patients undergoing percutaneous coronary intervention.
MedLine Citation:
PMID:  18585506     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Thrombocytopenia (TP) is a common baseline abnormality in patients undergoing percutaneous coronary intervention (PCI). Whether TP has any influence on the outcome of PCI patients is unknown. Our aim was to determine if TP at baseline impacts on inhospital mortality in patients undergoing PCI at our institution. METHODS: From April 2000 until October 2005, 11,021 PCI procedures were performed at the University Health Network in Toronto, Canada. Baseline platelet count was recorded in 10,821 (98.2%) cases. Patients with platelets <150 x 10(9)/L were assigned to the TP group (n = 639), and those with > or =150 x 10(9)/L to the normal platelet group (n = 10,182). Clinical, angiographic, procedural, and inhospital outcome data were collected prospectively. Multivariable analysis was performed using logistic regression. RESULTS: In-hospital death rate was higher in the TP group (1.9% vs 0.6%, P < .001) due to an increased mortality in TP patients undergoing urgent (3.55% vs 1.15%, P < .001) but not elective (0% vs 0.04%, P = 1.0) PCI. Major bleeding (1.7% vs 0.8%, P < .05) and gastrointestinal bleeding (1.1% vs 0.5%, P < .05) complications were greater in the TP group. Multivariate analysis demonstrated that baseline TP was an independent predictor of inhospital mortality (odds ratio 2.07 [1.1-4.1], P = .035). CONCLUSIONS: Baseline TP is an independent predictor of inhospital mortality in patients undergoing PCI for urgent indications. Thrombocytopenia should be considered an important addition to PCI risk prediction models to improve their precision and clinical applicability.
Christopher B Overgaard; Joan Ivanov; Peter H Seidelin; Mina Todorov; Karen Mackie; Vladimír Dzavík
Related Documents :
19194106 - The risk of gallbladder stone formation is increased in patients with predialysis chron...
17531566 - Relation of body mass index to outcome in patients with known or suspected coronary art...
17020756 - Asymmetric dimethylarginine (adma) and hyperhomocysteinemia in patients with acute myoc...
18480666 - Patients with end-stage renal disease and acute myocardial infarction have poor short-t...
21977026 - Swallowing in parkinson patients versus healthy controls: reliability of measurements i...
17219066 - Esophageal mucosal sensitivity: possible links with clinical presentations in patients ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-04-03
Journal Detail:
Title:  American heart journal     Volume:  156     ISSN:  1097-6744     ISO Abbreviation:  Am. Heart J.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-30     Completed Date:  2008-07-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  120-4     Citation Subset:  AIM; IM    
Interventional Cardiology Program, Peter Munk Cardiac Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Angioplasty, Transluminal, Percutaneous Coronary / methods,  mortality*
Case-Control Studies
Confidence Intervals
Coronary Angiography
Coronary Disease / mortality*,  radiography,  therapy*
Follow-Up Studies
Hospital Mortality / trends*
Middle Aged
Multivariate Analysis
Odds Ratio
Postoperative Complications / mortality
Predictive Value of Tests
Retrospective Studies
Risk Assessment
Severity of Illness Index
Survival Analysis
Thrombocytopenia / diagnosis*,  epidemiology
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Prevalence and extent of dyslipidemia and recommended lipid levels in US adults with and without car...
Next Document:  Safety and effectiveness of drug-eluting stents among diabetic patients: a propensity analysis.