Document Detail

Thrombocytopenia associated with environmental exposure to polyurethane.
MedLine Citation:
PMID:  1951307     Owner:  NLM     Status:  MEDLINE    
Few chemicals in the environment have been implicated as causes of isolated thrombocytopenia, and the evidence is usually less than convincing because the patients were not rechallenged with the chemical in vivo. In the present paper, a child is reported with the onset of thrombocytopenia in temporal association with environmental exposure to polyurethane. Five years after the initial thrombocytopenia had resolved, an inadvertent in vivo rechallenge with environmental polyurethane resulted in recurrence of the thrombocytopenia. This recurrence, together with the fact that only 1-4% of cases of idiopathic thrombocytopenic purpura in children recur, provided strong evidence for a causal role for the polyurethane exposure in this patient's thrombocytopenia. In summary, environmental exposure to polyurethane should be considered in the differential diagnosis of acquired thrombocytopenia in childhood.
A D Michelson
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of hematology     Volume:  38     ISSN:  0361-8609     ISO Abbreviation:  Am. J. Hematol.     Publication Date:  1991 Oct 
Date Detail:
Created Date:  1991-12-10     Completed Date:  1991-12-10     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7610369     Medline TA:  Am J Hematol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  145-6     Citation Subset:  IM    
Department of Pediatrics, University of Massachusetts Medical School, Worcester 01655.
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MeSH Terms
Child, Preschool
Diagnosis, Differential
Environmental Exposure*
Polyurethanes / adverse effects*
Thrombocytopenia / chemically induced*,  diagnosis
Grant Support
Reg. No./Substance:

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