| Thrombocytopenia associated with antithrombotic therapy in patients with cardiovascular diseases: diagnosis and treatment. | |
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MedLine Citation:
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PMID: 18828644 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Agents with antiplatelet and anticoagulant activity have been proved to be effective in reducing the incidence of complications following acute coronary syndrome, percutaneous coronary intervention, and cardiopulmonary bypass. However, these agents, including heparin, glycoprotein IIb/IIIa receptor inhibitors, and thienopyridines, are associated with increased risk of bleeding and thrombocytopenia and have been administered together with increasing frequency in a variety of cardiovascular settings. Therefore, clinicians must be familiar with the safety and rational use of these potent antithrombotic agents. Clinical features of thrombocytopenia range from bleeding to thrombosis, even death, and therapy is very different depending on the underlying cause. Additionally, patients may sometimes need urgent intervention or surgery. Thus, it is essential to quickly discriminate the etiology and start appropriate therapy. This review highlights the pathogenesis, clinical and laboratory manifestation, differential diagnosis, and treatment of antithrombotic drug-induced thrombocytopenia in cardiovascular diseases. |
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Authors:
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Burcak Kilickiran Avci; Ali Oto; Osman Ozcebe |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: American journal of cardiovascular drugs : drugs, devices, and other interventions Volume: 8 ISSN: 1175-3277 ISO Abbreviation: Am J Cardiovasc Drugs Publication Date: 2008 |
Date Detail:
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Created Date: 2008-10-02 Completed Date: 2009-01-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100967755 Medline TA: Am J Cardiovasc Drugs Country: New Zealand |
Other Details:
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Languages: eng Pagination: 327-39 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Faculty of Medicine, Baskent University, Istanbul, Turkey. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cardiovascular Diseases
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drug therapy* Diagnosis, Differential Drug Monitoring Fibrinolytic Agents / adverse effects*, therapeutic use Heparin / adverse effects, therapeutic use Humans Platelet Glycoprotein GPIIb-IIIa Complex / antagonists & inhibitors Pyridines / adverse effects, therapeutic use Thrombocytopenia / chemically induced*, diagnosis, therapy |
| Chemical | |
Reg. No./Substance:
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0/Fibrinolytic Agents; 0/Platelet Glycoprotein GPIIb-IIIa Complex; 0/Pyridines; 0/thienopyridine; 9005-49-6/Heparin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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