Document Detail

Thrombocytopaenia and intraventricular haemorrhage in very premature infants: a tale of two cities.
MedLine Citation:
PMID:  22294474     Owner:  NLM     Status:  Publisher    
ObjectiveTo study whether the incidence of intraventricular haemorrhage (IVH) in very premature infants (<32 weeks gestation) with thrombocytopaenia is lower when using a liberal platelet-transfusion guideline compared with a restrictive guideline.Study designA retrospective cohort study comparing the incidence of IVH in very premature infants with thrombocytopaenia (platelet count <150×10(9)/l) admitted between 2007 and 2008 to two neonatal intensive care unit in The Netherlands. The restrictive platelet-transfusion unit (N=353 infants <32 weeks gestation) transfused only in case of active haemorrhage and a platelet count <50×10(9)/l. The liberal-transfusion unit (N=326 infants <32 weeks gestation) transfused according to predefined platelet count thresholds. Primary outcome was the incidence and severity of IVH in infants with thrombocytopaenia in both units.ResultsThe number of infants with thrombocytopaenia that received a platelet transfusion was significantly lower in the restrictive-transfusion unit compared with the liberal-transfusion unit, 15% (21/145) versus 31% (41/141), (p<0.001). The incidence of IVH in infants with thrombocytopaenia in the restrictive-transfusion and liberal-transfusion units was 30% (44/145) and 29% (41/141), respectively (p=0.81). The incidence of severe IVH (grade 3 or 4) in the restrictive-transfusion and liberal-transfusion units was 8% (12/145) and 11% (16/141), respectively (p=0.38).ConclusionIn the restrictive-transfusion unit, the rate of platelet transfusions was significantly lower, but the incidence and severity of IVH was similar to the liberal-transfusion unit.
Jeannette S von Lindern; Christian V Hulzebos; Arend F Bos; Anneke Brand; Frans J Walther; Enrico Lopriore
Related Documents :
22834884 - Comparison of temporal artery and axillary temperatures in healthy newborns.
21975504 - Use of emergency ultrasound in the diagnostic evaluation of an infant with vomiting.
23278554 - Rapidly fatal multiorgan langerhans cell histiocytosis in a neonate.
25197944 - In search of ortolani: the man and the method.
25036534 - Neonatal hyperekplexia with homozygous p.r392h mutation in glra1.
18754394 - Use of newborn screening program blood spots for exposure assessment: declining levels ...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-31
Journal Detail:
Title:  Archives of disease in childhood. Fetal and neonatal edition     Volume:  -     ISSN:  1468-2052     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-2-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9501297     Medline TA:  Arch Dis Child Fetal Neonatal Ed     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1Division of Neonatology, Department of Paediatrics, Leiden University Medical Center, Leiden, The Netherlands.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  C reactive protein: impact on peripheral tissue oxygenation and perfusion in neonates.
Next Document:  Risk factors for early sudden deaths and severe apparent life-threatening events.