Document Detail

Thrombocythaemia and pregnancy.
MedLine Citation:
PMID:  12763489     Owner:  NLM     Status:  MEDLINE    
The diagnosis of essential thrombocythaemia (ET) is considered when all causes of reactive (secondary) thrombocytosis have been excluded in a patient with a persistent thrombocytosis. Among the chronic myeloproliferative disorders, ET has the highest proportion of young as well as female patients affected. As such, the optimal management of ET during pregnancy becomes an important issue. Although ET is not a contraindication to childbearing, the risks to both the fetus and mother are increased, and would-be-parents should be counselled regarding these. Obstetric complications occurring at higher than expected rates include spontaneous abortion in the first-trimester. Maternal complications, both haemorrhagic and thrombotic, are reported relatively infrequently. It is generally difficult to make specific management recommendations because of the relative rarity of the association between ET and pregnancy, which has precluded adequately powered controlled trials. In this communication, we review our own experience as well as that of other investigators on the subject matter and provide management guidelines that are based on best available information.
Michelle A Elliott; Ayalew Tefferi
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Best practice & research. Clinical haematology     Volume:  16     ISSN:  1521-6926     ISO Abbreviation:  Best Pract Res Clin Haematol     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-05-23     Completed Date:  2004-03-04     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  101120659     Medline TA:  Best Pract Res Clin Haematol     Country:  England    
Other Details:
Languages:  eng     Pagination:  227-42     Citation Subset:  IM    
Department of Hematology and Internal Medicine, Section of Scientific Publications, Mayo Clinic and Mayo Foundation, Mayo Medical School, 200 First Street SW, Rochester, MN 55905, USA.
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MeSH Terms
Disease Management
Pregnancy Complications, Hematologic / etiology*,  therapy
Pregnancy Outcome
Thrombocythemia, Essential / complications*,  therapy
Treatment Outcome

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