Document Detail

Thrombocytemia as a predictor of portal hypertension in schistosomiasis.
MedLine Citation:
PMID:  11117568     Owner:  NLM     Status:  MEDLINE    
Sufferers of schistosomiasis mansoni can evolve a clinical form of the disease associated with portal hypertension. To differentiate this form, routine clinical tests and biological indices were evaluated. In all, 54 HBsAg- and HCV-negative patients were studied, 42 with schistosomiasis and 12 normal volunteers. Using clinical criteria, ultrasonography, and endoscopy, the schistosomiasis patients were classified into two groups: mild chronic form (MS, N = 14) and chronic form associated with portal hypertension (PH, N = 28). The laboratory parameters of the MS group did not differ from the controls. The PH group differed from the others in prothrombin index, thrombocytemia, gamma-glutamyltransferase, serum alpha2-macroglobulin, and the calculated indices. ROC plot cutoff levels verified that isolated thrombocytemia was the most efficient marker for discrimination of the PH and MS forms. Thrombocytemia of 130 x 10(9) platelets/liter discriminated the groups with an 86% accuracy when all patients were analyzed and 96% when only schistosomiasis patients who did not consume alcohol were included.
M R Souza; C F Toledo; D R Borges
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  45     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2000-12-14     Completed Date:  2001-01-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1964-70     Citation Subset:  AIM; IM    
Department of Medicine, Universidade Federal de São Paulo, Brazil.
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MeSH Terms
Hypertension, Portal / diagnosis*
Liver Function Tests
Middle Aged
Platelet Count
Predictive Value of Tests
Schistosomiasis mansoni / diagnosis*
Thrombocytosis / diagnosis*

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