| Thromboatherosclerotic complications in hypertensives: results of the Stockholm Metoprolol (secondary prevention) Trial. | |
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MedLine Citation:
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PMID: 3293399 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The outcome of postinfarction patients with a history of hypertension who participated in a randomized, double-blind, secondary prevention study with metoprolol or placebo treatment for 3 years has been evaluated. There were 41 patients in the placebo group and 35 patients in the metoprolol group. Elevated blood pressure was treated primarily by the addition of thiazide diuretics. Blood pressures were nearly identical in the two treatment groups. During the 3 years, 11 patients died in the placebo group and seven died in the metoprolol group. Occurrence of nonfatal events was also higher in the placebo than in the treated group: 12 patients vs one patient for reinfarction (p less than 0.005), three patients vs no patients for coronary artery bypass grafting, four patients vs no patients for cerebrovascular events, and one patient vs no patients for lower limb amputation. The total number of patients with any event was 24 vs eight (p less than 0.01). The present results may imply that treatment after infarction with metoprolol reduces nonfatal thromboatherosclerotic complications, especially nonfatal reinfarctions, in patients with a history of hypertension. However, inasmuch as the results were obtained from a retrospective subgroup analysis, they must be interpreted with caution. |
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Authors:
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G Olsson |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: American heart journal Volume: 116 ISSN: 0002-8703 ISO Abbreviation: Am. Heart J. Publication Date: 1988 Jul |
Date Detail:
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Created Date: 1988-08-12 Completed Date: 1988-08-12 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 334-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, Karolinska Institutet, Danderyd Hospital, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Arteriosclerosis
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epidemiology*,
etiology,
mortality Cause of Death Clinical Trials as Topic Double-Blind Method Humans Hypertension / complications*, drug therapy, mortality Metoprolol / therapeutic use* Myocardial Infarction / complications Prospective Studies Random Allocation Sweden Thrombosis / epidemiology*, etiology, mortality Time Factors |
| Chemical | |
Reg. No./Substance:
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37350-58-6/Metoprolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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