| Thrombin in myocardial ischemia-reperfusion during cardiac surgery. | |
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MedLine Citation:
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PMID: 19559265 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Thrombin is a multifunctional protease with procoagulant, pro-inflammatory, and pro-apoptotic effects. Thrombin has direct potentially adverse effects on the endothelium and on cardiomyocytes, which are independent of its procoagulant effects, and it has emerged as a possible mediator of ischemia-reperfusion injury. Several lines of experimental evidence specifically implicate thrombin to be involved in myocardial ischemia-reperfusion injury. Cardiopulmonary bypass increases thrombin generation progressively, but reperfusion after myocardial ischemia induces an additional distinct and rapid increase in thrombin generation. Clinical studies have shown that thrombin formation during cardiac surgery, especially during myocardial reperfusion, is involved with myocardial damage and impaired hemodynamic recovery. Therefore, strategies to improve thrombin control during cardiopulmonary bypass might be beneficial. |
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Authors:
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Peter Raivio; Riitta Lassila; Jari Petäjä |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: The Annals of thoracic surgery Volume: 88 ISSN: 1552-6259 ISO Abbreviation: Ann. Thorac. Surg. Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-06-29 Completed Date: 2009-08-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 15030100R Medline TA: Ann Thorac Surg Country: Netherlands |
Other Details:
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Languages: eng Pagination: 318-25 Citation Subset: AIM; IM |
Affiliation:
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Department of Cardiothoracic Surgery, Helsinki University Central Hospital, Helsinki, Finland. peter.raivio@hus.fi |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anticoagulants / therapeutic use* Biological Markers / blood Cardiac Surgical Procedures / adverse effects, methods* Cardiopulmonary Bypass / adverse effects, methods Coronary Artery Bypass / adverse effects, methods Female Humans Intraoperative Complications / prevention & control Male Myocardial Reperfusion / adverse effects*, methods Myocardial Reperfusion Injury / etiology, mortality, prevention & control* Prognosis Risk Assessment Sensitivity and Specificity Survival Analysis Thrombin / adverse effects*, drug effects, metabolism Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 0/Biological Markers; EC 3.4.21.5/Thrombin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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