Document Detail


Thrombin in myocardial ischemia-reperfusion during cardiac surgery.
MedLine Citation:
PMID:  19559265     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thrombin is a multifunctional protease with procoagulant, pro-inflammatory, and pro-apoptotic effects. Thrombin has direct potentially adverse effects on the endothelium and on cardiomyocytes, which are independent of its procoagulant effects, and it has emerged as a possible mediator of ischemia-reperfusion injury. Several lines of experimental evidence specifically implicate thrombin to be involved in myocardial ischemia-reperfusion injury. Cardiopulmonary bypass increases thrombin generation progressively, but reperfusion after myocardial ischemia induces an additional distinct and rapid increase in thrombin generation. Clinical studies have shown that thrombin formation during cardiac surgery, especially during myocardial reperfusion, is involved with myocardial damage and impaired hemodynamic recovery. Therefore, strategies to improve thrombin control during cardiopulmonary bypass might be beneficial.
Authors:
Peter Raivio; Riitta Lassila; Jari Petäjä
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  88     ISSN:  1552-6259     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-29     Completed Date:  2009-08-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  318-25     Citation Subset:  AIM; IM    
Affiliation:
Department of Cardiothoracic Surgery, Helsinki University Central Hospital, Helsinki, Finland. peter.raivio@hus.fi
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MeSH Terms
Descriptor/Qualifier:
Animals
Anticoagulants / therapeutic use*
Biological Markers / blood
Cardiac Surgical Procedures / adverse effects,  methods*
Cardiopulmonary Bypass / adverse effects,  methods
Coronary Artery Bypass / adverse effects,  methods
Female
Humans
Intraoperative Complications / prevention & control
Male
Myocardial Reperfusion / adverse effects*,  methods
Myocardial Reperfusion Injury / etiology,  mortality,  prevention & control*
Prognosis
Risk Assessment
Sensitivity and Specificity
Survival Analysis
Thrombin / adverse effects*,  drug effects,  metabolism
Treatment Outcome
Chemical
Reg. No./Substance:
0/Anticoagulants; 0/Biological Markers; EC 3.4.21.5/Thrombin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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