| Thrombin generation in chronic obstructive pulmonary disease: dependence on plasma factor composition. | |
| | |
MedLine Citation:
|
PMID: 21624643 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is associated with an increased risk for thromboembolic events. We investigated thrombin generation profiles in COPD patients and their dependence on plasma factor/inhibitor composition. METHODS: Factors (f) (fII, fV, fVII, fVIII, fIX, fX), antithrombin, protein C (PC) and free tissue factor pathway inhibitor (fTFPI) from 60 COPD patients (aged 64.2 ± 10.1 years; a mean forced expiratory volume in 1 second [FEV(1)], 55.6 ± 15.8% of predicted values) were compared with those for 43 controls matched for age, sex, weight and smoking. Patients receiving anticoagulation were excluded. Using each individual's plasma coagulation protein composition, tissue factor-initiated thrombin generation was assessed computationally. RESULTS: COPD patients had higher fII (115 ± 16 vs 102 ± 10%, p < 0.0001), fV (114 ± 19 vs 102 ± 12%, p = 0.0002), fVII (111 ± 15 vs 102 ± 17%, p = 0.002), fVIII (170 ± 34 vs 115 ± 27%, p < 0.0001), and fIX (119 ± 21 vs 107 ± 17%, p = 0.003), and lower fTFPI (17.7 ± 3.2 vs 18.9 ± 3.2 ng/ml, p = 0.047) compared with controls, while fX, antithrombin, and PC were similar in both groups. Computational thrombin generation profiles showed that compared with controls, COPD patients had higher maximum thrombin levels (+28.3%, p < 0.0001), rates of thrombin generation (+46.1%, p < 0.0001) and total thrombin formation (+14.4%, p < 0.001), together with shorter initiation phase of thrombin generation (p < 0.0001) and the time to maximum thrombin levels (p < 0.0001). Thrombin generation profiles in COPD patients can be normalized via correction of fII, fVIII , fIX and TFPI. The severity of COPD and inflammatory markers were not associated with thrombin generation profiles. CONCLUSIONS: Prothrombotic phenotype in COPD patients is largely driven by increased prothrombin, fVIII, fIX, and lower fTFPI. |
| | |
Authors:
|
Anetta Undas; Milosz Jankowski; Przemysław Kaczmarek; Krzysztof Sladek; Kathleen Brummel-Ziedins |
Related Documents
:
|
19453363 - Proteomic identification and profiling of canine lymphoma patients. 6682493 - Radiologic evaluation of the mediastinum in myasthenia gravis. 18655403 - Vitamin b12 deficiency common in primary hypothyroidism. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-05-31 |
Journal Detail:
|
Title: Thrombosis research Volume: 128 ISSN: 1879-2472 ISO Abbreviation: Thromb. Res. Publication Date: 2011 Oct |
Date Detail:
|
Created Date: 2011-09-29 Completed Date: 2012-01-19 Revised Date: 2013-02-08 |
Medline Journal Info:
|
Nlm Unique ID: 0326377 Medline TA: Thromb Res Country: United States |
Other Details:
|
Languages: eng Pagination: e24-8 Citation Subset: IM |
Copyright Information:
|
Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
|
Institute of Cardiology, Jagiellonian University Medical College, Krakow, Poland. mmundas@cyf-kr.edu.pl |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Antithrombins / blood Blood Coagulation* Blood Coagulation Factor Inhibitors / blood* Blood Coagulation Factors / metabolism* Blood Coagulation Tests Case-Control Studies Female Forced Expiratory Volume Humans Kinetics Lipoproteins / blood Lung / physiopathology Male Middle Aged Phenotype Poland Protein C / metabolism Pulmonary Disease, Chronic Obstructive / blood*, drug therapy, physiopathology Thrombin / metabolism* Vital Capacity |
| Grant Support | |
ID/Acronym/Agency:
|
HL46703/HL/NHLBI NIH HHS; P01 HL046703-16A1/HL/NHLBI NIH HHS; P01 HL046703-17/HL/NHLBI NIH HHS; P01 HL046703-18/HL/NHLBI NIH HHS; P01 HL046703-19/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Antithrombins; 0/Blood Coagulation Factor Inhibitors; 0/Blood Coagulation Factors; 0/Lipoproteins; 0/Protein C; 0/lipoprotein-associated coagulation inhibitor; EC 3.4.21.5/Thrombin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Changes in water quality of the River Frome (UK) from 1965 to 2009: Is phosphorus mitigation finally...
Next Document: Epoprostenol inhibits human platelet-leukocyte mixed conjugate and platelet microparticle formation ...