Document Detail

Thrombin-cleaved osteopontin is increased in urine of patients with rheumatoid arthritis.
MedLine Citation:
PMID:  20156944     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To measure concentrations of the thrombin-cleaved isoform of osteopontin (OPN) in urine and plasma of patients with rheumatoid arthritis (RA), and to assess whether levels of thrombin-cleaved OPN are associated with measures of RA. METHODS: Subjects comprised 70 patients with RA, 20 patients with osteoarthritis (OA), and 46 healthy controls. RA disease activity was evaluated by tender joint count, swollen joint count, patient's global assessment of disease activity, erythrocyte sedimentation rate (ESR), and levels of C-reactive protein (CRP), matrix metalloproteinase-3 (MMP-3), and rheumatoid factor (RF), as well as 28-joint count Disease Activity Score (DAS28). OPN levels in plasma and urine were measured by ELISA. RESULTS: Median levels of thrombin-cleaved OPN in urine (U-half) were significantly higher in RA patients (143.5 pmol/mmol Cr) than in healthy controls (67.9 pmol/mmol Cr) or OA patients (69.8 pmol/mmol Cr). Thrombin-cleaved OPN was not detected in plasma. U-half levels correlated significantly with levels of CRP (r = 0.26, p = 0.03), ESR (r = 0.26, p = 0.03), and RF (r = 0.28, p = 0.03). Median U-half levels were significantly higher in patients with stage III (249.9 pmol/mmol Cr) and IV (251.6 pmol/mmol Cr) disease than in patients with stage I (98.6 pmol/mmol Cr) disease. CONCLUSION: Our results suggest that urine levels of the thrombin-cleaved isoform of OPN may reflect the severity of active inflammatory arthritis in patients with RA.
Kiori Shio; Hiroko Kobayashi; Tomoyuki Asano; Rie Saito; Haruyo Iwadate; Hiroshi Watanabe; Hirofumi Sakuma; Tetsuya Segawa; Masahiro Maeda; Hiromasa Ohira
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Publication Detail:
Type:  Journal Article     Date:  2010-02-15
Journal Detail:
Title:  The Journal of rheumatology     Volume:  37     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-02     Completed Date:  2010-06-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  704-10     Citation Subset:  IM    
Department of Internal Medicine II, Fukushima Medical University School of Medicine, Hikarigaoka, Fukushima, Japan.
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MeSH Terms
Aged, 80 and over
Arthritis, Rheumatoid / blood,  urine*
Blood Sedimentation
C-Reactive Protein / metabolism
Enzyme-Linked Immunosorbent Assay
Inflammation / blood,  urine*
Matrix Metalloproteinase 3 / blood
Middle Aged
Osteoarthritis / blood,  urine
Osteopontin / blood,  urine*
Pain Measurement
Protein Isoforms / blood,  urine
Rheumatoid Factor / blood
Severity of Illness Index
Thrombin / metabolism*
Reg. No./Substance:
0/Protein Isoforms; 106441-73-0/Osteopontin; 9007-41-4/C-Reactive Protein; 9009-79-4/Rheumatoid Factor; EC; EC Metalloproteinase 3

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