Document Detail


Thrombin binding to human brain and spinal cord.
MedLine Citation:
PMID:  6645628     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thrombin, a serine protease that regulates hemostasis, has been shown to stimulate the formation of cGMP in murine neuroblastoma cells. The nervous system in vivo thus may be postulated to respond to this blood-borne factor after it breaches the blood-brain barrier, as in trauma. Human alpha-thrombin was radiolabeled with 125I and shown to bind rapidly, reversibly, and with high affinity to human brain and spinal cord. These findings indicate the presence of specific thrombin-binding sites in nervous tissue and may have important clinical implications.
Authors:
M McKinney; R M Snider; E Richelson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Mayo Clinic proceedings     Volume:  58     ISSN:  0025-6196     ISO Abbreviation:  Mayo Clin. Proc.     Publication Date:  1983 Dec 
Date Detail:
Created Date:  1984-01-26     Completed Date:  1984-01-26     Revised Date:  2013-12-13    
Medline Journal Info:
Nlm Unique ID:  0405543     Medline TA:  Mayo Clin Proc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  829-31     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Binding Sites
Brain / metabolism*
Clone Cells / metabolism
Hirudins / pharmacology
Humans
Iodine Radioisotopes
Mice
Neuroblastoma / metabolism
Radioligand Assay
Spinal Cord / metabolism*
Thrombin / metabolism*
Grant Support
ID/Acronym/Agency:
AM 07147/AM/NIADDK NIH HHS; MH 08823/MH/NIMH NIH HHS; MH 27692/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Hirudins; 0/Iodine Radioisotopes; EC 3.4.21.5/Thrombin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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