Document Detail

Thrombin-antithrombin III-complex & fibrin degradation products in plasma: surgery and postoperative deep venous thrombosis.
MedLine Citation:
PMID:  2205019     Owner:  NLM     Status:  MEDLINE    
Thrombin-antithrombin-III complexes (TAT) & D-dimer in plasma, and fibrin(ogen) degradation products (FDP) in serum, were measured in 48 patients subjected to total hip arthroplasty. Blood samples were collected on days -1, 0, 1, 3, 7 and 10. Five patients developed postoperative deep vein thrombosis (DVT) diagnosed by venography. A characteristic pattern of TAT and D-dimer secondary to surgery was demonstrated. A poor correlation was found between ELISA- and latex-D-dimer concentrations after the operation. Patients with DVT had significantly higher TAT-levels preoperatively, and on day 0, 7 and 10. The concentration of FDP was significantly elevated in patients with DVT on day 7 and that of ELISA D-dimer on days 0 & 10. None of the assays are clinically valuable for purposes of postoperative screening for DVT. The preoperative plasma TAT concentration may represent a valuable predictive marker of postoperative DVT.
L N Jørgensen; B Lind; O Hauch; A Leffers; E Albrecht-Beste; L A Konradsen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Thrombosis research     Volume:  59     ISSN:  0049-3848     ISO Abbreviation:  Thromb. Res.     Publication Date:  1990 Jul 
Date Detail:
Created Date:  1990-10-18     Completed Date:  1990-10-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0326377     Medline TA:  Thromb Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  69-76     Citation Subset:  IM    
Department of Orthopedic Surgery, Central Hospital, Hillerød, Denmark.
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MeSH Terms
Aged, 80 and over
Antithrombin III / metabolism*
Enzyme-Linked Immunosorbent Assay
Fibrin Fibrinogen Degradation Products / metabolism*
Hip Prosthesis
Middle Aged
Peptide Hydrolases / metabolism*
Postoperative Complications / blood*
Surgical Procedures, Operative*
Thrombophlebitis / blood*,  etiology
Reg. No./Substance:
0/Fibrin Fibrinogen Degradation Products; 0/antithrombin III-protease complex; 0/fibrin fragment D; 9000-94-6/Antithrombin III; EC 3.4.-/Peptide Hydrolases

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