| Thrombin-activatable fibrinolysis inhibitor is associated with severity and outcome of severe meningococcal infection in children. | |
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MedLine Citation:
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PMID: 18021301 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND OBJECTIVES: In pediatric meningococcal sepsis, an imbalance between coagulation and fibrinolysis and proinflammatory action play major roles. We hypothesized that thrombin activatable fibrinolysis inhibitor (TAFI) and/or TAFI activation markers are involved in the pathogenesis of meningococcal sepsis. PATIENTS AND METHODS: Children with severe meningococcal sepsis (n = 112) previously included in Rotterdam-based trials participated in this study. Clinical and laboratory parameters and severity scores were assessed. TAFI and TAFI activation markers were determined: TAFI activation peptide (TAFI-AP) and (in)activated TAFI [TAFIa(i)]. The -438G/A, Ala147Thr, and Thr325Ile polymorphisms were genotyped. RESULTS: TAFI levels were significantly decreased in patients with meningococcal disease at admission compared to the convalescence state. TAFI was decreased in patients with septic shock vs. those with no shock. TAFI-AP levels were increased in patients with disseminated intravascular coagulation (DIC) vs. patients without DIC. TAFI-AP and TAFIa(i) were significantly increased in non-survivors vs. survivors. TAFI-AP levels and the TAFI-AP/TAFI ratio were also strongly correlated to severity scores and laboratory parameters. The TAFI 325Ile/Ile genotype was overrepresented in patients with DIC. CONCLUSIONS: Activation markers of TAFI were associated with the occurrence of DIC and mortality in meningococcal sepsis patients. A determination of TAFI, TAFI-AP, and TAFIa(i) is required to enable coherent interpretation of the role of TAFI in disease. |
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Authors:
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M Emonts; E L E de Bruijne; A H C Guimarães; P J Declerck; F W G Leebeek; M P M de Maat; D C Rijken; J A Hazelzet; A Gils |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-11-15 |
Journal Detail:
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Title: Journal of thrombosis and haemostasis : JTH Volume: 6 ISSN: 1538-7836 ISO Abbreviation: J. Thromb. Haemost. Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-01-24 Completed Date: 2008-05-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101170508 Medline TA: J Thromb Haemost Country: England |
Other Details:
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Languages: eng Pagination: 268-76 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Erasmus MC-Sophia, Rotterdam, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Carboxypeptidase U / blood*, genetics Child Child, Preschool Disseminated Intravascular Coagulation / blood, epidemiology, etiology Enzyme Activation Female Genetic Predisposition to Disease Genotype Humans Infant Male Meningococcal Infections / blood*, complications, microbiology, mortality Mutation, Missense Neisseria meningitidis / classification, isolation & purification Point Mutation Serotyping Severity of Illness Index Shock, Septic / blood, epidemiology, etiology Survival Analysis Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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EC 3.4.17.20/Carboxypeptidase U |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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