Document Detail


Threshold of toxicological concern (TTC) in food safety assessment.
MedLine Citation:
PMID:  12052639     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The threshold of toxicological concern (TTC) is a principle which refers to the possibility of establishing a human exposure threshold value for all chemicals, below which there is no appreciable risk to human health. The concept that exposure thresholds can be identified for individual chemicals in the diet is already widely embodied in practice of many regulatory bodies in setting acceptable daily intakes (ADIs) for chemicals whose toxicological profile is known. However, the TTC concept goes further than this in proposing that a de minimis value can be identified for many chemicals, including those of unknown toxicity, taking the chemical structure into consideration. This concept forms the scientific basis of the US Food and Drug Administration (FDA) '1995 Threshold of Regulation' for indirect food additives. The TTC principle has also been adopted by the Joint FAO/WHO Expert Committee on Food Additives (JECFA) in its evaluations of flavouring substances. The establishment of a more widely accepted TTC would benefit consumers, industry and regulators. In precluding extensive toxicity testing and safety evaluations when human intakes are below such a threshold, TTC would focus limited resources of time, cost, animal use and expertise on the testing and evaluation of substances with greater potential to pose risks to human health and contribute to a reduction in the use of animals. An International Life Sciences Institute (ILSI)-Europe expert group has examined this TTC principle, which was based on general toxicity endpoints (including carcinogenicity), for its applicability in food safety evaluation. In addition, the group examined specific endpoints, such as neurotoxicity, immunotoxicity and developmental toxicity. The results of the expert group's considerations including the development of a guideline to apply the principle are discussed.
Authors:
Robert Kroes; Gunhild Kozianowski
Related Documents :
24890399 - Beneficial properties of natural phenols: highlight on protection against pathological ...
24188309 - Chemistry, technology, and nutraceutical functions of celery (apium graveolens l.): an ...
11831339 - Effect of arthrocentesis on tmj disturbance of mouth closure with loud clicking: a prel...
6856619 - The interrelationships between methionine, choline, and sulfate in turkey diets.
8062109 - Effects of cultivar, pelleting and enzyme addition on nutritive value of barley in poul...
24272009 - Aggregation pheromone ofdrosophila mauritiana, drosophila yakuba, anddrosophila rajasek...
16549449 - Sesamin is one of the major precursors of mammalian lignans in sesame seed (sesamum ind...
21155809 - The quality of commercially available nutraceutical supplements and food sources.
21249159 - Polyamines in foods: development of a food database.
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Toxicology letters     Volume:  127     ISSN:  0378-4274     ISO Abbreviation:  Toxicol. Lett.     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-06-07     Completed Date:  2002-07-11     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7709027     Medline TA:  Toxicol Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  43-6     Citation Subset:  IM    
Affiliation:
IRAS, Utrecht University, P.O. Box 80176, NL-3508 TD, The Netherlands. rmkroes@worldonline.nl
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Carcinogenicity Tests
Carcinogens / analysis,  toxicity
Databases, Factual
Food Additives / analysis,  toxicity
Food Contamination / analysis,  prevention & control*
Humans
No-Observed-Adverse-Effect Level
Public Health / legislation & jurisprudence,  standards*
Risk Assessment / methods*
Risk Factors
Chemical
Reg. No./Substance:
0/Carcinogens; 0/Food Additives

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Food contamination by metals and pesticides in the European Union. Should we worry?
Next Document:  Interactions by carcinogenic metal compounds with DNA repair processes: toxicological implications.