| Threshold of regional cerebral blood flow for infarction in patients with acute cerebral ischemia. | |
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MedLine Citation:
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PMID: 16424835 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Threshold of regional cerebral blood flow (rCBF) for cerebral tissue survival in relation to time was studied in patients with acute cerebral ischemia with xenon-enhanced computed tomography (XeCT). Case 1: A 58-year-old man with right hemiparesis, total aphasia and a high intensity area of 1 cm 2 in the left insula on diffusion weighted image underwent XeCT CBF study before and after intra-arterial local thrombolytic therapy (IALT) on the occluded middle cerebral artery (MCA) 4 hours and 7 hours after stroke onset, respectively. Case 2: A 65-year-old woman with recurrent transient ischemic attacks (TIAs) caused by severe stenosis of the left MCA underwent XeCT CBF study 5 hours after onset of the last attack. XeCT was conducted by 5-min wash-in method. In Case 1 the rCBF in the pre-IALT MCA territory was 4 to 19 ml/100 g/min. The area where rCBF in the post-IALT increased to above 15 ml/100g/min were saved, but the other area where it remained in the 9 to 14 ml/100 g/min evolved into infarct on subsequent CT scan/MR (magnetic resonance) imaging. The patient was discharged with only mild motor dysphasia. In Case 2 the left corona radiata showed rCBF of 7 ml/100 g/min and this area evolved into infarct on MR imaging. The patient was discharged home with right hemiparesis. Our results showed validity of the rCBF threshold in acute cerebral ischemia reported by Jones et al. Residual rCBF in the acute stage of cerebral ischemic stroke can predict the fate of the lesion. |
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Authors:
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M Ohashi; A Tsuji; M Kaneko; M Matsuda |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of neuroradiology. Journal de neuroradiologie Volume: 32 ISSN: 0150-9861 ISO Abbreviation: J Neuroradiol Publication Date: 2005 Dec |
Date Detail:
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Created Date: 2006-01-20 Completed Date: 2006-02-28 Revised Date: 2008-02-20 |
Medline Journal Info:
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Nlm Unique ID: 7705086 Medline TA: J Neuroradiol Country: France |
Other Details:
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Languages: eng Pagination: 337-41 Citation Subset: IM |
Affiliation:
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Department of Neurosurgery, Shiga University of Medical Science, Ohtsu, Shiga 520-2192, Japan. mmrm@belle.shiga-med.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Brain Ischemia / complications, physiopathology*, radiography Cerebrovascular Circulation / physiology* Female Humans Male Middle Aged Stroke / etiology, physiopathology*, radiography Tomography, X-Ray Computed Xenon / diagnostic use |
| Chemical | |
Reg. No./Substance:
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7440-63-3/Xenon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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