| Threshold-like pattern of neuronal activation in the hypothalamus during treadmill running: establishment of a minimum running stress (MRS) rat model. | |
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MedLine Citation:
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PMID: 17524508 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Despite the indication that the hypothalamo-pituitary-adrenal (HPA) axis is activated during treadmill running, there have not been any studies focusing on the relationship between exercise intensity and region-specific neural activities in hypothalamus. To address this, rats were subjected to 30 min of running, either at middle (supra-LT, 25 m min(-1)) or low speeds (sub-LT, 15 m min(-1)), and c-Fos-(+) cells were counted and compared with control rats. Significant increases in blood glucose and lactate levels, and plasma ACTH and osmolality levels were observed during supra-LT running. Only supra-LT running significantly increased c-Fos induction in various hypothalamic regions, namely, the medial preoptic area (MPO), periventricular nucleus (Pe), suprachiasmatic nucleus (SCN), supraoptic nucleus (SON), parvocellular division of the paraventricular nucleus (pPVN), anterior hypothalamic area (AH), arcuate nucleus (ARC) and posterior hypothalamic nucleus (PH). However, sub-LT caused no effect on c-Fos accumulation. This indicates that the hypothalamus responds uniquely to running in a threshold-like pattern distinct from the speed-dependent pattern previously reported for the medulla oblongata [Ohiwa et al., 2006a,b]. In addition, these results showed a physiologic basis for mild exercise useful for establishing our minimum running stress (MRS) rat model, or the running conditions that minimize the activation of the HPA axis. |
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Authors:
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Hideaki Soya; Akira Mukai; Custer C Deocaris; Nao Ohiwa; Hyukki Chang; Takeshi Nishijima; Takahiko Fujikawa; Kenji Togashi; Tsuyoshi Saito |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-04-13 |
Journal Detail:
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Title: Neuroscience research Volume: 58 ISSN: 0168-0102 ISO Abbreviation: Neurosci. Res. Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-08-13 Completed Date: 2007-12-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8500749 Medline TA: Neurosci Res Country: Ireland |
Other Details:
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Languages: eng Pagination: 341-8 Citation Subset: IM |
Affiliation:
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Laboratory of Exercise Biochemistry, University of Tsukuba Graduate School of Comprehensive Human Sciences, Tsukuba 305-8574, Japan. hsoya@taiiku.tsukuba.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenocorticotropic Hormone
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blood Animals Behavior, Animal Blood Glucose / metabolism Disease Models, Animal Hypothalamus / pathology* Immunohistochemistry / methods Lactic Acid / blood, metabolism* Male Neurons / metabolism* Proto-Oncogene Proteins c-fos / metabolism Rats Rats, Wistar Running* Stress, Psychological / metabolism*, pathology* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Proto-Oncogene Proteins c-fos; 50-21-5/Lactic Acid; 9002-60-2/Adrenocorticotropic Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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