Document Detail

Threshold level or not for low-density lipoprotein cholesterol.
MedLine Citation:
PMID:  11383373     Owner:  NLM     Status:  MEDLINE    
As drugs, such as the statins, and other therapies demonstrate the ability to significantly lower levels of low-density lipoprotein cholesterol (LDL-C), one issue is whether there is a lower threshold below which no further decline in coronary heart disease occurs. Those who evaluate the data from multiple trials and conclude that no significant decrease in coronary event rates occurs at or below 125 mg/dL suggest using this level as a guideline for clinical application of cholesterol-lowering therapy. On the other hand, analysis of the results of the same population and primary prevention studies concludes that no such threshold exists. The issues affected by the decision of whether to use a threshold include costs to the healthcare system for additional physician time, tests, and medication; unknown clinical events and safety related to very low LDL-C; and resource prioritization to an unestablished therapeutic approach.
P J Barter; F M Sacks
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The American journal of managed care     Volume:  7     ISSN:  1088-0224     ISO Abbreviation:  Am J Manag Care     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-05-31     Completed Date:  2001-06-21     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9613960     Medline TA:  Am J Manag Care     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S125-31     Citation Subset:  H    
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MeSH Terms
Anticholesteremic Agents / therapeutic use*
Coronary Disease / blood,  prevention & control*
Lipoproteins, LDL / blood*
Risk Factors
United States
Reg. No./Substance:
0/Anticholesteremic Agents; 0/Lipoproteins, LDL

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