Document Detail


The 25(OH)D/PTH threshold in black women.
MedLine Citation:
PMID:  20685862     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONTEXT: Black women have lower 25-hydroxyvitamin D [25(OH)D] and higher PTH than white women. Recent evidence implicates PTH in adverse cardiovascular outcomes.
OBJECTIVE: The objective of the study was to determine whether PTH increases at lower 25(OH)D levels (the threshold) in black compared with white women.
DESIGN: Healthy black and white women, aged 20-80 yr were recruited to participate in a cross-sectional study of body-composition in black and white women. Measurement of serum 25(OH)D and PTH were carried out.
SETTING: The study was a convenience sample recruited from a community setting.
PATIENTS: Healthy black and white women were recruited by advertising and a direct mail campaign in a comparative study of body composition. Age ranged from 20-to 80 yr. There were 148 black and 129 white premenopausal participants and 87 black and 139 white postmenopausal participants.
MAIN OUTCOME: The main outcome was to determine whether the threshold for 25(OH)D/PTH differs in black and white women.
RESULTS: A threshold of 37 nmol/liter (95% confidence interval 35-40) was found for black and 59 nmol/liter (95% confidence interval 56-63) for white women. These two values were significantly different (P < 0.001).
CONCLUSIONS: Black women have an increase in serum PTH at a lower 25(OH)D level than white women. Negative health outcomes of higher PTH should be investigated in black women.
Authors:
John F Aloia; Ding-Geng Chen; Henian Chen
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-08-04
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  95     ISSN:  1945-7197     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-05     Completed Date:  2010-12-10     Revised Date:  2013-03-05    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5069-73     Citation Subset:  AIM; IM    
Affiliation:
Bone Mineral Research Center, Winthrop-University Hospital, Mineola, New York 11501, USA. jaloia@winthrop.org
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
African Americans*
Aged
Aged, 80 and over
Body Composition
Cross-Sectional Studies
European Continental Ancestry Group
Female
Humans
Immunoassay
Middle Aged
Parathyroid Hormone / blood*
Vitamin D / analogs & derivatives*,  blood
Grant Support
ID/Acronym/Agency:
IH R01AG015325/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
0/Parathyroid Hormone; 1406-16-2/Vitamin D; 64719-49-9/25-hydroxyvitamin D
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Progesterone increases manganese superoxide dismutase expression via a cAMP-dependent signaling medi...
Next Document:  Circulating levels of soluble klotho and FGF23 in X-linked hypophosphatemia: circadian variance, eff...