Document Detail

Threshold of carotid artery back pressure for delayed neuronal injury in the hippocampus after bilateral common carotid artery occlusion in gerbils.
MedLine Citation:
PMID:  2401899     Owner:  NLM     Status:  MEDLINE    
The threshold of carotid artery back pressure for the development of neuronal injury in the hippocampus was determined in gerbils following bilateral carotid artery occlusion of 5 or 10 min. Arterial back pressure was measured during ischemia at the left carotid bifurcation distal to the vascular occlusion, and neuronal injury evaluated one week after ischemia by counting the number of surviving neurons in the left hippocampal CA1 sector. With an arterial back pressure below 5 mm Hg, the mean density of surviving neurons decreased from 199 +/- 16/mm (mean +/- SD) to less than 21/mm both after 5 and 10 min ischemia (P less than 0.05). With a back pressure of between 5 and 15 mm Hg, neuronal density was 117 +/- 77/mm (not significantly different from control) after 5 min, and 24 +/- 18/mm (P less than 0.05) after 10 min ischemia. Above 15 mm Hg neither 5 nor 10 min ischemia produced significant neuronal damage. Thus, at threshold arterial back pressure, induction of neuronal injury in the hippocampus depends on the duration of ischemia, indicating progressive impairment of microcirculation with longer periods of ischemia.
T Kuroiwa; P Bonnekoh; K A Hossmann
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  97     ISSN:  0022-510X     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  1990 Jul 
Date Detail:
Created Date:  1990-10-24     Completed Date:  1990-10-24     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  251-9     Citation Subset:  IM    
Max-Planck-Institute for Neurological Research, Department for Experimental Neurology, Cologne, F.R.G.
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MeSH Terms
Blood Pressure*
Carotid Arteries / physiology,  physiopathology*
Hippocampus / blood supply,  pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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