| Threshold suprachoroidal-transretinal stimulation current required by different-size electrodes in rabbit eyes. | |
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MedLine Citation:
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PMID: 20847573 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Aims: To evaluate the threshold currents required by different-size electrodes under various stimulus parameters by suprachoroidal-transretinal stimulation (STS) in rabbit eyes. Methods: An electrode array with 4 differently sized electrode contacts (50, 150, 350 and 500 μm in diameter) was implanted into the suprachoroidal space of the rabbit eyes. The electrically evoked potential was recorded extradurally on the visual cortex, and the threshold was measured for each size electrode by a biphasic current pulse at the pulse durations of 0.25, 0.5, 0.75 and 1.0 ms. Stimuli were applied at 1, 2 and 4 Hz. Results: The current thresholds with the 50-μm electrode were 80 ± 21.2 and 41.4 ± 6.5 μA for 0.25- and 1.0-ms pulses, respectively. That obviously exceeded the limits for safe stimulation with platinum. Compared to 350- and 500-μm electrodes, a lower threshold can be obtained by the 150-μm electrode just at 1 Hz. And the most significant change in the threshold as the stimulus frequency increased to 4 Hz was obtained by the 150-μm electrode with short-duration pulse (0.25 ms). Conclusion: The large surface electrode with long-duration pulses may be preferable for the STS prosthesis. And stimuli with low frequency are suggested to be the safer choice. |
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Authors:
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Ting Liang; Liming Zhao; Xiaohong Sui; Chuanqing Zhou; Qiushi Ren; Yanhua Qi |
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Publication Detail:
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Type: Journal Article Date: 2010-09-17 |
Journal Detail:
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Title: Ophthalmic research Volume: 45 ISSN: 1423-0259 ISO Abbreviation: Ophthalmic Res. Publication Date: 2011 |
Date Detail:
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Created Date: 2011-03-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0267442 Medline TA: Ophthalmic Res Country: Switzerland |
Other Details:
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Languages: eng Pagination: 113-21 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 S. Karger AG, Basel. |
Affiliation:
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Department of Ophthalmology, Second Affiliated Hospital of Harbin Medical University, Harbin, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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