| Threonine-deficient diets induced changes in hepatic bioenergetics. | |
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MedLine Citation:
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PMID: 19228885 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Diets deficient in an indispensable amino acid are known to suppress food intake in rats. Few studies were focused at understanding how amino acid-deficient diets may elicit biochemical changes at the mitochondrial level. The goal of this study was to evaluate mitochondrial function in rats fed diets with 0.00, 0.18, 0.36, and 0.88% threonine (Thr) (set at 0, 30, 60, and 140% of Thr requirement for growth). Here, it is described for the first time that Thr-deficient diets induce a specific uncoupling of mitochondria in liver, especially with NADH-linked substrates, not observed in heart (except for Thr-devoid diet). The advantage of this situation would be to provide ATP to support growth and maintenance when high-quality protein food (or wealth of high-quality food in general) is available, whereas Thr-deficient diets (or deficient-quality protein food) promote the opposite, increasing mitochondrial uncoupling in liver. The uncoupling with NADH substrates would favor the use of nutrients as energy sources with higher FADH-to-NADH ratios, such as fat, minimizing the first irreversible NADH-dependent catabolism of many amino acids, including Thr, thus enhancing the use of the limiting amino acid for protein synthesis when a low quality protein source is available. |
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Authors:
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Catherine M Ross-Inta; Yi-Fan Zhang; Andrew Almendares; Cecilia Giulivi |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2009-02-19 |
Journal Detail:
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Title: American journal of physiology. Gastrointestinal and liver physiology Volume: 296 ISSN: 0193-1857 ISO Abbreviation: Am. J. Physiol. Gastrointest. Liver Physiol. Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-04-27 Completed Date: 2009-06-02 Revised Date: 2010-09-23 |
Medline Journal Info:
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Nlm Unique ID: 100901227 Medline TA: Am J Physiol Gastrointest Liver Physiol Country: United States |
Other Details:
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Languages: eng Pagination: G1130-9 Citation Subset: IM |
Affiliation:
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Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, Davis, California 95616, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphate
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metabolism Animal Nutritional Physiological Phenomena* Animals Body Weight Dietary Proteins / administration & dosage, metabolism* Disease Models, Animal Eating Energy Metabolism* Flavin-Adenine Dinucleotide / metabolism Liver / metabolism* Male Mitochondria, Heart / metabolism Mitochondria, Liver / metabolism* Myocardium / metabolism NAD / metabolism Oxidative Phosphorylation Protein Deficiency / metabolism*, physiopathology Rats Rats, Sprague-Dawley Threonine / administration & dosage, deficiency* Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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ES-005707/ES/NIEHS NIH HHS; ES-012691/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Dietary Proteins; 146-14-5/Flavin-Adenine Dinucleotide; 53-84-9/NAD; 56-65-5/Adenosine Triphosphate; 72-19-5/Threonine |
| Comments/Corrections | |
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