Document Detail

Three's company: the fission yeast actin cytoskeleton.
MedLine Citation:
PMID:  21145239     Owner:  NLM     Status:  MEDLINE    
How the actin cytoskeleton assembles into different structures to drive diverse cellular processes is a fundamental cell biological question. In addition to orchestrating the appropriate combination of regulators and actin-binding proteins, different actin-based structures must insulate themselves from one another to maintain specificity within a crowded cytoplasm. Actin specification is particularly challenging in complex eukaryotes where a multitude of protein isoforms and actin structures operate within the same cell. Fission yeast Schizosaccharomyces pombe possesses a single actin isoform that functions in three distinct structures throughout the cell cycle. In this review we explore recent studies in fission yeast that help unravel how different actin structures operate in cells.
David R Kovar; Vladimir Sirotkin; Matthew Lord
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2010-12-07
Journal Detail:
Title:  Trends in cell biology     Volume:  21     ISSN:  1879-3088     ISO Abbreviation:  Trends Cell Biol.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-07     Completed Date:  2011-04-25     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  9200566     Medline TA:  Trends Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  177-87     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ltd. All rights reserved.
Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, IL 60637, USA.
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MeSH Terms
Actins / metabolism*
Cell Cycle
Cytoskeleton / metabolism*
Protein Binding
Schizosaccharomyces / cytology,  metabolism*
Grant Support
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