Document Detail


Three young osteosarcoma patients with small adenocarcinoma or atypical adenomatous hyperplasia of the lung.
MedLine Citation:
PMID:  21030925     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Three young osteosarcoma patients with adenocarcinoma (AD) or atypical adenomatous hyperplasia (AAH) of the lung are reported. A 14-year-old male patient with femoral osteosarcoma had solitary AD (case 1); a 23-year-old female patient with femoral osteosarcoma had AAH and lung metastasis (case 2); and a 17-year-old male patient with humeral osteosarcoma had AD and lung metastasis of osteosarcoma (case 3). They have been the youngest patients with lung cancer or AAH in our hospital. The maximum diameter of each lung tumor on computed tomography (CT) was 0.5, 0.6, and 0.5 cm, respectively. On immunohistochemical analyses, the p53 was positive in both AD and osteosarcoma and negative in both AAH and osteosarcoma. On genomic analyses, p53 mutation was detected in only one osteosarcoma (case 3). Epidermal growth factor receptor (EGFR) mutations, short in-frame deletion in exon 19, and insertion in exon 20 were found in AD, but not in AAH or osteosarcoma. There was no apparent genomic relationship between AD/AAH and osteosarcoma in the young patients in this study. Advances in CT and its applications to osteosarcoma patients as a method of assessing lung metastasis might contribute in large part to the detection of AD/AAH in patients younger than 30.
Authors:
Kenji Shiraishi; Takeshi Mori; Yasuomi Ohba; Kazunori Iwatani; Kentaro Yoshimoto; Ken-ichi Iyama
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia     Volume:  16     ISSN:  2186-1005     ISO Abbreviation:  Ann Thorac Cardiovasc Surg     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-29     Completed Date:  2011-04-21     Revised Date:  2012-06-18    
Medline Journal Info:
Nlm Unique ID:  9703158     Medline TA:  Ann Thorac Cardiovasc Surg     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  358-61     Citation Subset:  IM    
Affiliation:
Department of Thoracic Surgery, Graduate School of Medical Sciences, Kumamoto University Hospital, Kumamoto University, Kumamoto, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / complications*,  pathology,  secondary
Adolescent
Bone Neoplasms / complications*,  pathology
Female
Femur
Humans
Humerus
Hyperplasia / complications
Lung Neoplasms / complications*,  pathology,  secondary
Male
Osteosarcoma / complications*,  pathology,  secondary
Precancerous Conditions / complications*
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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