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Three-year survival of patients with chronic systolic heart failure due to hypertension - analysis of prognostic factors.
MedLine Citation:
PMID:  23111565     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
INTRODUCTION Despite advances in medicine, chronic systolic heart failure (CHF) due to hypertension still constitutes a serious clinical problem.   OBJECTIVES To determine risk factors for death in 3-year follow-up in patients with CHF due to hypertension.  PATIENTS AND METHODS The analysis encompassed 140 consecutive in-hospital stable patients with CHF [left ventricular end diastolic diameter (LVEDd)>57mm, left ventricular ejection fraction (LVEF)<40%], free from epicardial artery stenosis (>30% vessel lumen), significant heart defect, diabetes, neoplastic disease or chronic kidney disease, with a history of hypertension (minimum 5 years), and receiving angiotensin convertase inhibitors, β-adrenolytics, spironolactone, furosemid and digoxin for ≥3 months.  The follow-up began on admission after performing laboratory tests, resting electrocardiograph and echocardiograph, six-minute walk test, coronarography and endomyocardial biopsy. Late follow-up data was obtained from six-monthly follow-up visits or by telephone.  RESULTS The analysis encompassed 130 out of 140 patients aged 47.8±7.9 years old. The three-year mortality rate was 18.5%. Independent risk factors for death were: LVEF (hazard ratio (HR) 0.881, p<0.05), serum glucose (HR 1.266, p<0.01), N-terminal pro-B-type natriuretic peptide (NT pro-BNP) (HR 1.369 per each 100ng, p<0.001) and bilirubin (HR 1.057, p<0.05).  CONCLUSIONS Beside left ventricular ejection fraction (LVEF) and serum NT pro-BNP, also glucose and bilirubin are independent risk factors for death in patients with CHF due to hypertension.  
Authors:
Monika Szymik; Bożena Szyguła-Jurkiewicz; Robert Partyka; Aleksander Owczarek; Beata Spinczyk; Jerzy Chudek; Lech Poloński
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-30
Journal Detail:
Title:  Polskie Archiwum Medycyny Wewnetrznej     Volume:  -     ISSN:  1897-9483     ISO Abbreviation:  Pol. Arch. Med. Wewn.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401225     Medline TA:  Pol Arch Med Wewn     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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