Document Detail


Three-year risk of cervical precancer and cancer after the detection of low-risk human papillomavirus genotypes targeted by a commercial test.
MedLine Citation:
PMID:  24463663     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To investigate the risk of cervical precancer and cancer associated with detection of human papillomavirus (HPV) 6, 11, and 42.
METHODS: We used data from the New Mexico Human Papillomavirus Pap Registry. A stratified sample of 59,644 residual cervical cytology specimens from a population of 379,000 underwent HPV genotyping. We measured the 3-year cumulative incidence of cervical intraepithelial neoplasia grade 2 or more severe (CIN 2+) and grade 3 or more severe (CIN 3+) after detection of single HPV 6, 11, or 42 infections or single or multiple infections of HPV 6, 11, or 42 ("HPV 6, 11, 42, or combinations"; n=581).
RESULTS: The overall prevalence of a single infection of HPV 6, 11, or 42 was 0.8% (95% confidence interval [CI] 0.7-0.9%). The 3-year risks of CIN 2+ and CIN 3+ after HPV 6, 11, 42, or combinations infections (n=581) were 0.4% (CI 0.1-0.7%) for CIN 2+ and 0.0% for CIN 3+ (nota bene, no CI was calculable because no events occurred), respectively. By comparison, the 3-year risks of CIN 2+ and CIN 3+ after a negative HPV result (n=27,522) were 0.2% (95% CI 0.1-0.2%) and 0.1% (95% CI 0.0-0.1%), respectively.
CONCLUSION: Detection of HPV 6, 11, 42, or combinations in the absence of high-risk HPV types does not identify women at increased 3-year risk for cervical precancer. Testing for HPV 6, 11, 42, or combinations of those types should be discontinued because it has no proven benefit to patients.
LEVEL OF EVIDENCE: II.
Authors:
Philip E Castle; William C Hunt; Erika Langsfeld; Cosette M Wheeler;
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  123     ISSN:  1873-233X     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2014 Jan 
Date Detail:
Created Date:  2014-01-27     Completed Date:  2014-03-18     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  49-56     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Cervical Intraepithelial Neoplasia / epidemiology,  virology*
Female
Human papillomavirus 11*
Humans
New Mexico / epidemiology
Papillomavirus Infections / complications*,  epidemiology,  genetics
Risk Assessment
Uterine Cervical Dysplasia / epidemiology,  virology*
Uterine Cervical Neoplasms / epidemiology,  virology*
Grant Support
ID/Acronym/Agency:
U19 AI084081/AI/NIAID NIH HHS; U19AI084081/AI/NIAID NIH HHS
Investigator
Investigator/Affiliation:
Nancy E Joste / ; Walter Kinney / ; Cosette M Wheeler / ; William C Hunt / ; Deborah Thompson / ; Susan Baum / ; Linda Gorgos / ; Alan Waxman / ; David Espey / ; Jane McGrath / ; Steven Jenison / ; Mark Schiffman / ; Philip Castle / ; Vicki Benard / ; Debbie Saslow / ; Jane J Kim / ; Mark H Stoler / ; Jack Cuzick / ; Giovanna Rossi Pressley / ; Kevin English /

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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