Document Detail

Three-year follow up of term and near-term infants treated with inhaled nitric oxide.
MedLine Citation:
PMID:  12828583     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The present study describes the outcome at 3 years in term and near-term infants treated with inhaled nitric oxide (iNO) for persistent pulmonary hypertension of the newborn (PPHN). METHODS: The study population consisted of 18 infants delivered at 34 weeks by best obstetric estimate who were admitted to the neonatal intensive care units with a diagnosis of PPHN. RESULTS: Eighteen infants (mean gestational age 38.5 +/- 2.6 weeks, mean birthweight 3015 +/- 587 g) were treated with iNO. The mean oxygenation index before iNO was 27.2 +/- 15.2. Responses to iNO were classified into three groups: (i) early response in eight infants; (ii) late response in two; and (iii) poor response in eight infants. Three infants died within seven postnatal days. Fifteen surviving infants were followed up to 3 years. The mean developmental scale was 98.4 +/- 9.0. One infant was diagnosed with severe neurodevelopmental disability due to cerebral palsy. Another infant was diagnosed with mild neurodevelopmental disability because of a low developmental scale. No infant showed significant hearing loss. Five infants had reactive airway disease (RAD) at 18 months, these infants required a significantly longer duration of mechanical ventilation in their neonatal period than non-RAD infants (P = 0.02). The frequency of survival with normal neurodevelopmental outcome was significantly higher in the early response group than the late or poor response groups (P = 0.03). CONCLUSION: In iNO-treated PPHN, mortality and neurodevelopmental outcome were associated with response to iNO, and pulmonary outcome was associated with duration of mechanical ventilation.
Hiroyuki Ichiba; Satoko Matsunami; Fumihide Itoh; Toru Ueda; Yukinobu Ohsasa; Tsunekazu Yamano
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatrics international : official journal of the Japan Pediatric Society     Volume:  45     ISSN:  1328-8067     ISO Abbreviation:  Pediatr Int     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-06-27     Completed Date:  2003-10-14     Revised Date:  2008-05-21    
Medline Journal Info:
Nlm Unique ID:  100886002     Medline TA:  Pediatr Int     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  290-3     Citation Subset:  IM    
Department of Pediatrics, Osaka City University Graduate School of Medicine, Osaka City Sumiyoshi Hospital, Osaka, Japan.
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MeSH Terms
Administration, Inhalation
Follow-Up Studies
Gestational Age
Infant, Newborn
Infant, Premature, Diseases / drug therapy
Nitric Oxide / administration & dosage*
Persistent Fetal Circulation Syndrome / drug therapy*,  physiopathology
Treatment Outcome
Vasodilator Agents / administration & dosage*
Reg. No./Substance:
0/Vasodilator Agents; 10102-43-9/Nitric Oxide

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