| Three-year follow-up after intracoronary gamma radiation therapy for in-stent restenosis. Original WRIST. Washington Radiation for In-Stent Restenosis Trial. | |
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MedLine Citation:
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PMID: 12160759 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The Washington Radiation for In-Stent Restenosis Trial (WRIST) is a double-blinded randomized study evaluating the effects of intracoronary radiation therapy (IRT) in patients with in-stent restenosis (ISR). METHODS: One hundred and thirty patients with ISR (100 native coronary and 30 vein grafts) underwent PTCA, laser ablation, rotational atherectomy, and/or additional stenting (36% of lesions). Patients were randomized to either Iridium-192 IRT or placebo, with a prescribed dose of 15 Gy to a 2-mm radial distance from the center of the source. RESULTS: Angiographic restenosis (27% vs. 56%, P=.002) and target vessel revascularization (TVR; 26% vs. 66%, P<.001) were dramatically reduced at 6 months in IRT patients. Between 6 and 36 months, IRT compared to placebo patients had more target lesion revascularization (TLR; IRT=17% vs. placebo=2%, P=.002) and TVR (IRT=17% vs. placebo=3%, P=.009). At 3 years, the major adverse cardiac event (MACE) rate was significantly reduced with IRT (39% vs. 65%, P=.003). CONCLUSIONS: In WRIST, patients with ISR treated with IRT using 192Ir had a marked reduction in the need for repeat target lesion and vessel revascularization at 6 months, with the clinical benefit maintained at 3 years. |
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Authors:
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A E Ajani; R Waksman; A K Sharma; D H Cha; E Cheneau; R L White; D Canos; A D Pichard; L F Satler; K M Kent; E Pinnow; J Lindsay |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Cardiovascular radiation medicine Volume: 2 ISSN: 1522-1865 ISO Abbreviation: Cardiovasc. Radiat. Med. Publication Date: 2001 Oct-Dec |
Date Detail:
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Created Date: 2002-08-05 Completed Date: 2002-10-29 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 100888865 Medline TA: Cardiovasc Radiat Med Country: United States |
Other Details:
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Languages: eng Pagination: 200-4 Citation Subset: IM |
Affiliation:
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Washington Hospital Center and Washington Cancer Institute at the Washington Hospital Center, Washington, DC 20010, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Brachytherapy Coronary Restenosis / radiotherapy* Coronary Stenosis / therapy Double-Blind Method Female Follow-Up Studies Humans Iridium Radioisotopes / therapeutic use Male Middle Aged Prospective Studies Radiotherapy Dosage Stents* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Iridium Radioisotopes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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