| Three-year clinical and angiographic follow-up after intracoronary radiation : results of a randomized clinical trial. | |
MedLine Citation:
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PMID: 10653825 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Although several early trials indicate treatment of restenosis with radiation therapy is safe and effective, the long-term impact of this new technology has been questioned. The objective of this report is to document angiographic and clinical outcome 3 years after treatment of restenotic stented coronary arteries with catheter-based (192)Ir. METHODS AND RESULTS: A double-blind, randomized trial compared (192)Ir with placebo sources in patients with previous restenosis after coronary angioplasty. Over a 9-month period, 55 patients were enrolled; 26 were randomized to (192)Ir and 29 to placebo. At 3-year follow-up, target-lesion revascularization was significantly lower in the (192)Ir group (15. 4% versus 48.3%; P<0.01). The dichotomous restenosis rate at 3-year follow-up was also significantly lower in (192)Ir patients (33% versus 64%; P<0.05). In a subgroup of patients with 3-year angiographic follow-up not subjected to target-lesion revascularization by the 6-month angiogram, the mean minimal luminal diameter between 6 months and 3 years decreased from 2.49+/-0.81 to 2.12+/-0.73 mm in (192)Ir patients but was unchanged in placebo patients. CONCLUSIONS: The early clinical benefits observed after treatment of coronary restenosis with (192)Ir appear durable at late follow-up. Angiographic restenosis continues to be significantly reduced in (192)Ir-treated patients, but a small amount of late loss was observed between the 6-month and 3-year follow-up time points. No events occurred in the (192)Ir group to suggest major untoward effects of vascular radiotherapy. At 3-year follow-up, vascular radiotherapy continues to be a promising new treatment for restenosis. |
Authors:
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P S Teirstein; V Massullo; S Jani; J J Popma; R J Russo; R A Schatz; E M Guarneri; S Steuterman; K Sirkin; D A Cloutier; M B Leon; P Tripuraneni |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial |
Journal Detail:
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Title: Circulation Volume: 101 ISSN: 1524-4539 ISO Abbreviation: Circulation Publication Date: 2000 Feb |
Date Detail:
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Created Date: 2000-02-18 Completed Date: 2000-02-18 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 360-5 Citation Subset: AIM; IM |
Affiliation:
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Division of Cardiovascular Diseases, Scripps Clinic, La Jolla, CA 92037, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angioplasty, Balloon* Brachytherapy* / mortality Coronary Angiography* Coronary Disease / mortality, radiotherapy*, therapy Disease-Free Survival Double-Blind Method Female Follow-Up Studies Graft Occlusion, Vascular Humans Iridium Radioisotopes / therapeutic use* Male Myocardial Infarction / surgery, therapy Placebos Recurrence Stents* Survival Analysis |
| Chemical | |
Reg. No./Substance:
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0/Iridium Radioisotopes; 0/Placebos |
| Comments/Corrections | |
Comment In:
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Circulation. 2000 Feb 1;101(4):350-1
[PMID:
10653822
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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