Document Detail

Three-year analysis of microbial aetiology and antimicrobial susceptibilities of PD peritonitis.
MedLine Citation:
PMID:  16857609     Owner:  NLM     Status:  MEDLINE    
The first-line antibiotic treatment of peritoneal dialysis (PD) peritonitis has to cover the most common causative microorganisms. Our aim was to analyse antimicrobial sensitivities of different empirical protocols for initial therapy of PD peritonitis. We analysed the aetiological microorganisms of PD peritonitis and their antimicrobial sensitivities during a 36-month period. Clinical characteristics of the cases were recorded. Altogether 86 PD peritonitides were diagnosed during the study period. In 58 cases, microbial cultures were positive with 72 different causative agents. 28 cases (33%) were culture-negative. Over-representation of icodextrin users was noted among the culture-negative cases. Staphylococcus aureus was the most frequent causative agent, often leading to severe course of illness. Of antimicrobial protocols for initial treatment of peritonitis tested in vitro, the combination of a first-generation cephalosporin and an aminoglycoside was superior to the combination of a first-generation cephalosporin and ceftazidime as well as to fluoroquinolone monotherapy but similar to the combination of vancomycin and ceftazidime. Based on antimicrobial sensitivities we continue using an aminoglycoside in the empirical treatment of PD peritonitis. In the present material, users of icodextrin PD fluid were over-represented among patients with culture-negative peritonitis.
Heidi Leppänen; Kaj P Metsärinne; Jukka Nikoskelainen; Risto Tertti
Related Documents :
20674219 - Etiology of septic arthritis in children: an update for the new millennium.
1907759 - Bacteremia and septic arthritis caused by moraxella catarrhalis.
2692949 - Infectious arthritis caused by klebsiella. a report of two cases.
24345839 - The question of an infectious etiology or contribution to the pathogenesis of infantile...
10479919 - Pneumococcal arthritis in the wrist and ankle. a case report and short review of the li...
20851679 - A clinico-pathological conference on constrictive pericarditis secondary to rheumatoid ...
15556589 - Sonographic assessment of the submandibular space.
21351309 - Consistency between causality assessments obtained with two scales and their agreement ...
6335829 - Retinal manifestations of acquired immunodeficiency syndrome (aids). report of a case.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of infectious diseases     Volume:  38     ISSN:  0036-5548     ISO Abbreviation:  Scand. J. Infect. Dis.     Publication Date:  2006  
Date Detail:
Created Date:  2006-07-21     Completed Date:  2006-10-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0215333     Medline TA:  Scand J Infect Dis     Country:  Sweden    
Other Details:
Languages:  eng     Pagination:  645-9     Citation Subset:  IM    
Department of Internal Medicine, Turku University Central Hospital, Turku, Finland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aminoglycosides / pharmacology,  therapeutic use
Anti-Bacterial Agents / pharmacology,  therapeutic use
Cephalosporins / pharmacology,  therapeutic use
Cephalothin / pharmacology,  therapeutic use
Dialysis Solutions
Microbial Sensitivity Tests
Middle Aged
Peritoneal Dialysis / adverse effects*,  methods
Peritonitis / drug therapy,  etiology,  microbiology*
Retrospective Studies
Tobramycin / pharmacology,  therapeutic use
Vancomycin / pharmacology,  therapeutic use
Reg. No./Substance:
0/Aminoglycosides; 0/Anti-Bacterial Agents; 0/Cephalosporins; 0/Dialysis Solutions; 0/Glucans; 0/icodextrin; 1404-90-6/Vancomycin; 153-61-7/Cephalothin; 32986-56-4/Tobramycin; 50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Importance of rotavirus as a cause of gastroenteritis in Jordan: a hospital based study.
Next Document:  Serum concentrations of protease inhibitors as predictors of HIV-related clinical events in patients...