Document Detail


Three-year analysis of microbial aetiology and antimicrobial susceptibilities of PD peritonitis.
MedLine Citation:
PMID:  16857609     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The first-line antibiotic treatment of peritoneal dialysis (PD) peritonitis has to cover the most common causative microorganisms. Our aim was to analyse antimicrobial sensitivities of different empirical protocols for initial therapy of PD peritonitis. We analysed the aetiological microorganisms of PD peritonitis and their antimicrobial sensitivities during a 36-month period. Clinical characteristics of the cases were recorded. Altogether 86 PD peritonitides were diagnosed during the study period. In 58 cases, microbial cultures were positive with 72 different causative agents. 28 cases (33%) were culture-negative. Over-representation of icodextrin users was noted among the culture-negative cases. Staphylococcus aureus was the most frequent causative agent, often leading to severe course of illness. Of antimicrobial protocols for initial treatment of peritonitis tested in vitro, the combination of a first-generation cephalosporin and an aminoglycoside was superior to the combination of a first-generation cephalosporin and ceftazidime as well as to fluoroquinolone monotherapy but similar to the combination of vancomycin and ceftazidime. Based on antimicrobial sensitivities we continue using an aminoglycoside in the empirical treatment of PD peritonitis. In the present material, users of icodextrin PD fluid were over-represented among patients with culture-negative peritonitis.
Authors:
Heidi Leppänen; Kaj P Metsärinne; Jukka Nikoskelainen; Risto Tertti
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of infectious diseases     Volume:  38     ISSN:  0036-5548     ISO Abbreviation:  Scand. J. Infect. Dis.     Publication Date:  2006  
Date Detail:
Created Date:  2006-07-21     Completed Date:  2006-10-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0215333     Medline TA:  Scand J Infect Dis     Country:  Sweden    
Other Details:
Languages:  eng     Pagination:  645-9     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Turku University Central Hospital, Turku, Finland.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aminoglycosides / pharmacology,  therapeutic use
Anti-Bacterial Agents / pharmacology,  therapeutic use
Cephalosporins / pharmacology,  therapeutic use
Cephalothin / pharmacology,  therapeutic use
Dialysis Solutions
Female
Glucans
Glucose
Humans
Male
Microbial Sensitivity Tests
Middle Aged
Peritoneal Dialysis / adverse effects*,  methods
Peritonitis / drug therapy,  etiology,  microbiology*
Retrospective Studies
Tobramycin / pharmacology,  therapeutic use
Vancomycin / pharmacology,  therapeutic use
Chemical
Reg. No./Substance:
0/Aminoglycosides; 0/Anti-Bacterial Agents; 0/Cephalosporins; 0/Dialysis Solutions; 0/Glucans; 0/icodextrin; 1404-90-6/Vancomycin; 153-61-7/Cephalothin; 32986-56-4/Tobramycin; 50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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