Document Detail


Three-way complex translocations in infant acute myeloid leukemia with t(7;12)(q36;p13): the incidence and correlation of a HLXB9 overexpression.
MedLine Citation:
PMID:  19446746     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The t(7;12)(q36;p13) is one of the recurrent cytogenetic abnormalities that involves the ETV6 gene. It is found in patients suffering with infantile acute myeloid leukemia (AML). We reviewed the cytogenetic and clinical findings of 215 pediatric patients (ages </=17) who were diagnosed with AML to check for abnormalities of 7q and/or 12p. Fluorescence in situ hybridization (FISH) analysis using an ETV6 (12p13) break-apart probe was done to confirm the breakage of the ETV6 gene on 12p. We also performed immunohistochemistry to verify the upregulated expression of the HLXB9 protein, which is coded by the HLXB9 gene at 7q36. Three patients (1.4%) with t(7;12) were detected and they made up 15.8% of the patients who were less than 24 months old. New three-way complex translocations were found in two cases - t(5;7;12)(q31;q36;p13) and t(1;7;12)(q25;q36;p13) - and we detected these by performing FISH. All three patients died early during treatment due to multiple organ failure or relapse. HLXB9 overexpression was proven by immunohistochemistry for the first time in this study. In connection with this, we prudently propose that downregulation of the HLXB9 expression may be a new treatment strategy for AML patients with t(7;12).
Authors:
Joonhong Park; Myungshin Kim; Jihyang Lim; Yonggoo Kim; Kyungja Han; Jaewook Lee; Nak Gyun Chung; Bin Cho; Hack Ki Kim
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer genetics and cytogenetics     Volume:  191     ISSN:  1873-4456     ISO Abbreviation:  Cancer Genet. Cytogenet.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-18     Completed Date:  2009-07-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7909240     Medline TA:  Cancer Genet Cytogenet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  102-5     Citation Subset:  IM    
Affiliation:
Department of Laboratory Medicine, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul 137-701.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Bone Marrow / pathology
Child
Child, Preschool
Chromosome Banding
Chromosome Mapping
Chromosomes, Human, Pair 12*
Chromosomes, Human, Pair 7*
Gene Expression Regulation, Neoplastic
Homeodomain Proteins / genetics*
Humans
In Situ Hybridization, Fluorescence
Infant
Karyotyping
Leukemia, Myeloid, Acute / genetics*,  pathology
Metaphase
Transcription Factors / genetics*
Translocation, Genetic / genetics*
Chemical
Reg. No./Substance:
0/Homeodomain Proteins; 0/MNX1 protein, human; 0/Transcription Factors

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