Document Detail


Three- to 7-year follow-up after albendazole treatment of 68 patients with cystic echinococcosis (hydatid disease).
MedLine Citation:
PMID:  7944675     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sixty-eight cystic echinococcosis patients were each treated with 800 mg albendazole/day in four 28-day courses separated by 14-day drug-free intervals. Follow-up for 3-7 years showed that this treatment alone eradicated the cysts in many patients; in most of the remainder, disease progression stopped. Of the 59 patients with liver cyst(s), 41% were cured (all cysts disappeared), 17% showed marked improvement (> 25% contraction, complete consolidation), 24% limited improvement and 15% no change. Of the 12 patients with lung cyst(s), 72% were cured, 9% showed limited improvement and 18% showed no change (18%). No patient worsened but a recurrence occurred in two patients at about 56 months. The times taken to detect an initial cyst change and to detect cure were longer than is generally expected; initial cyst changes and cure could only be detected after 1 year in 12% and 69% of patients with liver cysts and 22% and 37% of those with lung cysts, respectively.
Authors:
J Nahmias; R Goldsmith; M Soibelman; J el-On
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Annals of tropical medicine and parasitology     Volume:  88     ISSN:  0003-4983     ISO Abbreviation:  Ann Trop Med Parasitol     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-11-14     Completed Date:  1994-11-14     Revised Date:  2009-05-18    
Medline Journal Info:
Nlm Unique ID:  2985178R     Medline TA:  Ann Trop Med Parasitol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  295-304     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Bylu Medical Center, Moztkin, Israel.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Age Factors
Albendazole / administration & dosage,  adverse effects,  therapeutic use*
Child
Echinococcosis / drug therapy*
Echinococcosis, Hepatic / drug therapy
Echinococcosis, Pulmonary / drug therapy
Female
Follow-Up Studies
Humans
Male
Middle Aged
Recurrence
Time Factors
Treatment Outcome
Grant Support
ID/Acronym/Agency:
NIAD N01-AI-45184/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
54965-21-8/Albendazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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