| Three red cell sodium transport systems in hypertensive and normotensive Utah adults. | |
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MedLine Citation:
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PMID: 6327514 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sodium-lithium countertransport (SLC), sodium-potassium cotransport (CoT), and ouabain binding to sodium-potassium adenosine triphosphatase (Na, K-ATPase) sites were measured on fresh erythrocytes from hypertensive and normotensive Utah subjects with and without a first-degree relative with hypertension. SLC was measured as Li+ efflux into NaCl and MgCl2 media from Li+-loaded cells (5-7 mM). CoT was measured by monitoring Na+ and K+ efflux from cells loaded to 20-30 mM Na+ and 20-30 mMK+. Ouabain binding was determined for fresh cells using 3H-ouabain. Subjects were selected from pedigrees that showed a prevalence of hypertension. SLC was significantly elevated in 26.5% of the hypertensive subjects (p less than 0.001) as well as in 12.8% of the normotensives with a hypertensive first-degree relative (p less than 0.05). Although elevated SLC and decreased CoT have previously been associated with hypertension, no hypertensive subject in this study exhibited both abnormalities. All subjects with elevated SLC had normal CoT. A positive correlation between SLC and CoT was observed. Few hypertensive subjects (11.8%) had decreased CoT. In the majority of subjects studied, both SLC and CoT were normal: hypertensives 61.8%, normotensives with a hypertensive first-degree relative 61.7%, and other normotensives 58.7%. The number of ouabain-binding sites was not significantly altered among hypertensives, or their relatives, even though there was a positive correlation between SLC and the number of ouabain-binding sites. |
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Authors:
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J B Smith; K O Ash; S C Hunt; W M Hentschel; W Sprowell; M M Dadone; R R Williams |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Hypertension Volume: 6 ISSN: 0194-911X ISO Abbreviation: Hypertension Publication Date: 1984 Mar-Apr |
Date Detail:
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Created Date: 1984-07-09 Completed Date: 1984-07-09 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7906255 Medline TA: Hypertension Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 159-66 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Binding Sites Biological Transport Erythrocytes / metabolism* Female Humans Hypertension / blood*, genetics Lithium / blood Male Middle Aged Ouabain / blood Pedigree Potassium / blood Sodium / blood* Sodium-Potassium-Exchanging ATPase / blood Utah |
| Grant Support | |
ID/Acronym/Agency:
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HL 24855-04/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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630-60-4/Ouabain; 7439-93-2/Lithium; 7440-09-7/Potassium; 7440-23-5/Sodium; EC 3.6.3.9/Sodium-Potassium-Exchanging ATPase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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