Document Detail


Three rearrangements of chromosome 5 in a patient with myelodysplastic syndrome: an atypical deletion 5q, a complex intrachromosomal rearrangement of chromosome 5, and a paracentric inversion of chromosome 5.
MedLine Citation:
PMID:  21156249     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report the case of a 74-year-old man who sought care for de novo myelodysplastic syndrome (RAEB-1). Conventional cytogenetic techniques showed a karyotype with two different deletions of the long arm of chromosome 5 distributed in three clones: 46,XY,del(1)(p34),del(5)(q14q23)[2]/46,XY,del(1)(p34),del(5)(q14q34)[10]/46,idem,inv(5)(q?11q?34)[7]. Precise characterization of the breakpoints, delineation of the deleted regions, identification of the complex intrachromosomal rearrangement of chromosome 5, and sequential accumulation of chromosomal abnormalities were elucidated by several fluorescence in situ hybridization analyses. We also assessed the clinical, biological, and cytogenetic evolution under lenalidomide treatment and after its interruption.
Authors:
Nathalie Douet-Guilbert; Audrey Basinko; Jean-Richard Eveillard; Frédéric Morel; Marie-Josée Le Bris; Nadia Guéganic; Clément Bovo; Angèle Herry; Christian Berthou; Marc De Braekeleer
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Cancer genetics and cytogenetics     Volume:  203     ISSN:  1873-4456     ISO Abbreviation:  Cancer Genet. Cytogenet.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-15     Completed Date:  2011-01-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7909240     Medline TA:  Cancer Genet Cytogenet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  303-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
Affiliation:
Laboratoire d'Histologie, Embryologie et Cytogénétique, Faculté de Médecine et des Sciences de la Santé, Université de Bretagne Occidentale, Brest, France.
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MeSH Terms
Descriptor/Qualifier:
Aged
Chromosome Banding
Chromosome Mapping
Chromosomes, Artificial, Bacterial
Chromosomes, Human, Pair 5*
Cytogenetics
Gene Rearrangement*
Humans
In Situ Hybridization, Fluorescence
Karyotyping
Male
Myelodysplastic Syndromes / genetics*
Thalidomide / analogs & derivatives,  pharmacology
Chemical
Reg. No./Substance:
191732-72-6/lenalidomide; 50-35-1/Thalidomide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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