Document Detail


Three polymorphisms in the IL-10 gene and the risk of HCV infection: a meta-analysis plus a Chinese Association Study involving 1140 subjects.
MedLine Citation:
PMID:  23013641     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The influence of an immunosuppressive cytokine, interleukin-10 (IL-10), on the outcome of hepatitis C virus (HCV) infection has been increasingly reported recently. A number of polymorphisms appear to control the level of IL-10 production. Among them, -592C/A, -819C/T and -1082G/A in the IL-10 gene are three most studied single nucleotide polymorphisms. To provide a more definitive conclusion about their association with the risk of HCV infection, a meta-analysis was performed by combining and summarizing a total of 17 studies. A biological justification for the choice of genetic model was provided. The results indicated no significant association between these IL-10 polymorphisms and the susceptibility to HCV infection [-592C/A: odds ratio (OR) 0.99, 95% confidence interval (CI) 0.78-1.25; -819C/T: OR 0.90, 95% CI 0.69-1.18; -1082G/A: OR 1.34, 95% CI 0.90-2.00]. However, this analysis did not account for the possible risk modifications by other factors, such as ethnicity and virus persistence. Therefore, the effects of ethnicity and virus persistence were investigated using Bayesian meta-regression and subgroup analysis. Finally, an extended case-control association study was conducted in a Chinese population involving 1140 subjects. Both serum level and genotype data of IL-10 -1082G/A were determined. As a result, a low prevalence of G allele was observed. Significantly higher IL-10 production was observed in HCV patients, especially patients with the GG genotype.
Authors:
J Li; Y Liu; F Xu; J Chen; Y Chen
Publication Detail:
Type:  Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't     Date:  2012-09-27
Journal Detail:
Title:  Epidemiology and infection     Volume:  141     ISSN:  1469-4409     ISO Abbreviation:  Epidemiol. Infect.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-03-29     Completed Date:  2013-05-20     Revised Date:  2013-06-29    
Medline Journal Info:
Nlm Unique ID:  8703737     Medline TA:  Epidemiol Infect     Country:  England    
Other Details:
Languages:  eng     Pagination:  893-904     Citation Subset:  IM    
Affiliation:
Department of Infectious Diseases, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Bayes Theorem
Case-Control Studies
China / epidemiology
Female
Gene Expression Regulation / immunology,  physiology
Genetic Predisposition to Disease*
Genotype
Hepacivirus*
Hepatitis C / epidemiology,  genetics,  immunology*
Humans
Interleukin-10 / blood,  genetics,  metabolism*
Male
Middle Aged
Models, Genetic
Odds Ratio
Polymorphism, Genetic*
Population Surveillance
Risk
Young Adult
Chemical
Reg. No./Substance:
0/IL10 protein, human; 130068-27-8/Interleukin-10

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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