Document Detail


Three polymorphisms associated with low hepatic lipase activity are common in African Americans.
MedLine Citation:
PMID:  9741704     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have shown previously that a hepatic lipase allele (designated -514T) is common among African Americans and contributes to low hepatic lipase activity in this population. To identify other hepatic lipase alleles associated with low hepatic lipase activity in this population, the coding region and intron-exon boundaries of the hepatic lipase gene were sequenced in 20 African American men with low hepatic lipase activity. Two polymorphisms (N193S and L334F) were associated with low post-heparin plasma hepatic lipase activity and were much more common in African Americans than in whites. This finding, together with our previous data on the -514T allele, indicates that at least three different hepatic lipase polymorphisms associated with low hepatic lipase activity are common among African Americans. Analysis of hepatic lipase haplotypes revealed that 97% of African Americans have at least one hepatic lipase allele that is associated with low hepatic lipase activity.
Authors:
L Nie; S Niu; G L Vega; L T Clark; A Tang; S M Grundy; J C Cohen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of lipid research     Volume:  39     ISSN:  0022-2275     ISO Abbreviation:  J. Lipid Res.     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1998-12-07     Completed Date:  1998-12-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376606     Medline TA:  J Lipid Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1900-3     Citation Subset:  IM    
Affiliation:
The Center for Human Nutrition, Department of Clinical Nutrition, University of Texas Southwestern Medical Center, Dallas 75235-9052, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
African Continental Ancestry Group / genetics*
Alleles
Exons
Genotype
Haplotypes
Humans
Introns
Lipase / genetics*,  metabolism
Liver / enzymology*
Male
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length*
Sequence Analysis, DNA
Grant Support
ID/Acronym/Agency:
HL-53917/HL/NHLBI NIH HHS; M-01-RR-00633/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
EC 3.1.1.3/Lipase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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