Document Detail

Three polymorphisms associated with low hepatic lipase activity are common in African Americans.
MedLine Citation:
PMID:  9741704     Owner:  NLM     Status:  MEDLINE    
We have shown previously that a hepatic lipase allele (designated -514T) is common among African Americans and contributes to low hepatic lipase activity in this population. To identify other hepatic lipase alleles associated with low hepatic lipase activity in this population, the coding region and intron-exon boundaries of the hepatic lipase gene were sequenced in 20 African American men with low hepatic lipase activity. Two polymorphisms (N193S and L334F) were associated with low post-heparin plasma hepatic lipase activity and were much more common in African Americans than in whites. This finding, together with our previous data on the -514T allele, indicates that at least three different hepatic lipase polymorphisms associated with low hepatic lipase activity are common among African Americans. Analysis of hepatic lipase haplotypes revealed that 97% of African Americans have at least one hepatic lipase allele that is associated with low hepatic lipase activity.
L Nie; S Niu; G L Vega; L T Clark; A Tang; S M Grundy; J C Cohen
Related Documents :
23859784 - Differential modulation of phenotypic composition of hiv-infected and -uninfected pbmcs...
23592504 - Transcriptomic analysis of peripheral blood mononuclear cells in rapid progressors in e...
2678174 - Skin manifestations of hiv infection.
24829544 - Strategies for the prevention of recurrent hepatitis b virus infection after liver tran...
20949114 - The role of interferon in hepatitis b therapy.
16433114 - The symptom experience of people living with hiv/aids in southern africa.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of lipid research     Volume:  39     ISSN:  0022-2275     ISO Abbreviation:  J. Lipid Res.     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1998-12-07     Completed Date:  1998-12-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376606     Medline TA:  J Lipid Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1900-3     Citation Subset:  IM    
The Center for Human Nutrition, Department of Clinical Nutrition, University of Texas Southwestern Medical Center, Dallas 75235-9052, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
African Continental Ancestry Group / genetics*
Lipase / genetics*,  metabolism
Liver / enzymology*
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length*
Sequence Analysis, DNA
Grant Support
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Surface enhanced Raman spectroscopic monitor of P. acnes lipid hydrolysis in vitro.
Next Document:  Micro- and macro-consequences of ooplasmic injections of early haploid male gametes.