Document Detail

Three oral formulations of methadone. A clinical and pharmacodynamic comparison.
MedLine Citation:
PMID:  10531630     Owner:  NLM     Status:  MEDLINE    
This study was done to determine whether there were any differences in subjective symptoms of opiate withdrawal or methadone pharmacodynamics among patients as they were switched between three different oral formulations of methadone. Patients enrolled in a three-way double-blind crossover trial of three methadone formulations. Subjective symptoms and pharmacodynamic measures were assessed throughout the study period. Eighteen patients were enrolled the study. No statistically significant differences in any of the pharmacodynamic parameters studied were found among the three methadone preparations. There was no significant difference among preparations in the rate and extent of rise and fall in plasma methadone levels during a 24-hour intensive sampling period. Subjective symptoms also did not correlate with methadone formulation. Intolerance to changes in methadone formulation, often observed clinically, do not appear to have a pharmacodynamic basis. Our findings support the notion that such change intolerance reflects factors other than the pharmacologic properties of the different formulations of methadone.
M N Gourevitch; D Hartel; P Tenore; K Freeman; I Marion; J Hecht; J Lowinson
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of substance abuse treatment     Volume:  17     ISSN:  0740-5472     ISO Abbreviation:  J Subst Abuse Treat     Publication Date:  1999 Oct 
Date Detail:
Created Date:  1999-11-15     Completed Date:  1999-11-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8500909     Medline TA:  J Subst Abuse Treat     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  237-41     Citation Subset:  IM    
Department Epidemiology and Social Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA.
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MeSH Terms
Chemistry, Pharmaceutical
Cross-Over Studies
Dose-Response Relationship, Drug
Double-Blind Method
Methadone / administration & dosage*,  blood,  pharmacokinetics*
Middle Aged
Narcotics / administration & dosage*,  blood,  pharmacokinetics*
Opioid-Related Disorders / blood,  psychology*,  rehabilitation*
Substance Withdrawal Syndrome / blood,  etiology
Treatment Outcome
Reg. No./Substance:
0/Narcotics; 76-99-3/Methadone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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