Document Detail


Three major haplotypes of the beta2 adrenergic receptor define psychological profile, blood pressure, and the risk for development of a common musculoskeletal pain disorder.
MedLine Citation:
PMID:  16741943     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Adrenergic receptor beta(2) (ADRB2) is a primary target for epinephrine. It plays a critical role in mediating physiological and psychological responses to environmental stressors. Thus, functional genetic variants of ADRB2 will be associated with a complex array of psychological and physiological phenotypes. These genetic variants should also interact with environmental factors such as physical or emotional stress to produce a phenotype vulnerable to pathological states. In this study, we determined whether common genetic variants of ADRB2 contribute to the development of a common chronic pain condition that is associated with increased levels of psychological distress and low blood pressure, factors which are strongly influenced by the adrenergic system. We genotyped 202 female subjects and examined the relationships between three major ADRB2 haplotypes and psychological factors, resting blood pressure, and the risk of developing a chronic musculoskeletal pain condition-Temporomandibular Joint Disorder (TMD). We propose that the first haplotype codes for lower levels of ADRB2 expression, the second haplotype codes for higher ADRB2 expression, and the third haplotype codes for higher receptor expression and rapid agonist-induced internalization. Individuals who carried one haplotype coding for high and one coding for low ADRB2 expression displayed the highest positive psychological traits, had higher levels of resting arterial pressure, and were about 10 times less likely to develop TMD. Thus, our data suggest that either positive or negative imbalances in ADRB2 function increase the vulnerability to chronic pain conditions such as TMD through different etiological pathways that imply the need for tailored treatment options.
Authors:
Luda Diatchenko; Amy D Anderson; Gary D Slade; Roger B Fillingim; Svetlana A Shabalina; Tomas J Higgins; Swetha Sama; Inna Belfer; David Goldman; Mitchell B Max; Bruce S Weir; William Maixner
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics     Volume:  141B     ISSN:  1552-4841     ISO Abbreviation:  Am. J. Med. Genet. B Neuropsychiatr. Genet.     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-06-19     Completed Date:  2006-08-16     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  101235742     Medline TA:  Am J Med Genet B Neuropsychiatr Genet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  449-62     Citation Subset:  IM    
Copyright Information:
(c) 2006 Wiley-Liss, Inc.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Blood Pressure / genetics*
Female
Gene Expression / genetics
Gene Frequency
Genetic Predisposition to Disease / genetics,  psychology
Genotype
Haplotypes / genetics*
Humans
Linear Models
Polymorphism, Genetic
Questionnaires
Receptors, Adrenergic, beta-2 / genetics*,  physiology
Risk Factors
Stress, Psychological / complications,  genetics*
Temporomandibular Joint Disorders / etiology,  genetics*
Grant Support
ID/Acronym/Agency:
DE016558/DE/NIDCR NIH HHS; DE07509/DE/NIDCR NIH HHS; NS045688/NS/NINDS NIH HHS; P01 DE007509-150009/DE/NIDCR NIH HHS; P01 NS045685/NS/NINDS NIH HHS; P01 NS045685-05/NS/NINDS NIH HHS; R01 DE016558/DE/NIDCR NIH HHS; R01 DE016558-04/DE/NIDCR NIH HHS
Chemical
Reg. No./Substance:
0/Receptors, Adrenergic, beta-2
Comments/Corrections

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