| Three hydroxylated lupeol-based triterpenoid esters isolated from the Eastern Nigeria mistletoe parasitic on Kola acuminata. | |
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MedLine Citation:
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PMID: 22007932 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Column fractionation and purification of an n-hexane fraction led to the isolation of three lupeol-based triterpenoid esters from the leaves of the Eastern Nigeria mistletoe, Loranthus micranthus Linn parasitic on a local kola nut tree, Kola acuminata. These three compounds were adequately characterised using a combination of UV/visible, IR, NMR ((13)C-NMR and (1)H-NMR), DEPT, MS and two-dimensional correlation (H-H COSY, Hetero-nuclear Single Quantum Correlation (HSQC), HMBC, NOE and NOESY) studies as 7β,15α-dihydroxyl-lup-20(29)-ene-3β-esters of palmitic (I), stearic (II) and eicosanoic acids (III). The characterisation of other isolated compounds is ongoing. Remarkably, this is the first report of the existence of fatty acid esters of an unusual 7β,15α-dihydroxylated lupeol in the Eastern Nigeria mistletoe. These isolated compounds might contribute in part to the numerous established bio-activities of the Eastern Nigeria mistletoes. |
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Authors:
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Edwin Ogechukwu Omeje; Patience Ogoamaka Osadebe; Charles Okechukwu Esimone; Chukwuemeka Sylvester Nworu; Akira Kawamura; Peter Proksch |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-19 |
Journal Detail:
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Title: Natural product research Volume: - ISSN: 1478-6427 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101167924 Medline TA: Nat Prod Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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a Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences , University of Nigeria , Nsukka 410001 , Nigeria. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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