Document Detail

Three histamine receptors (H1, H2 and H3) visualized in the brain of human and non-human primates.
MedLine Citation:
PMID:  1979518     Owner:  NLM     Status:  MEDLINE    
The distribution of histamine H1, H2 and H3 receptors in postmortem human and rhesus monkey brain was examined using receptor autoradiography. [125I]Iodobolpyramine, [125I]iodoaminopotentine and [3H](R) alpha-methylhistamine were used as ligands to label H1, H2 and H3 receptors respectively. The 3 receptor subtypes were identified in the human and monkey brains. Each receptor presented comparable distribution in the two primate brains. H1 and H2 receptors were particularly enriched in the caudate and putamen and observed in other brain areas such as the neocortex and hippocampus. H3-receptors were found to predominate in the basal ganglia where the highest densities were localized in the two segments of the globus pallidus. They were also observed in the hippocampus and cortical areas. The distribution of these 3 histamine receptors in the primate brain suggests the involvement of histaminergic mechanism in the functions of many brain areas. In particular, H2 and H3 receptors could play a role in the regulation of the basal ganglia functions in primates.
M I Martinez-Mir; H Pollard; J Moreau; J M Arrang; M Ruat; E Traiffort; J C Schwartz; J M Palacios
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain research     Volume:  526     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1990 Sep 
Date Detail:
Created Date:  1991-01-31     Completed Date:  1991-01-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  322-7     Citation Subset:  IM    
Preclinical Research, Sandoz Pharma Ltd., Basel, Switzerland.
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MeSH Terms
Aged, 80 and over
Brain Chemistry / physiology*
Guanidines / metabolism
Histamine Antagonists
Histamine H1 Antagonists / metabolism
Histamine H2 Antagonists / metabolism
Iodine Radioisotopes / diagnostic use
Macaca mulatta
Methylhistamines / metabolism
Middle Aged
Pyrilamine / analogs & derivatives,  metabolism
Radioligand Assay
Receptors, Histamine / analysis*
Receptors, Histamine H1 / analysis*
Receptors, Histamine H2 / analysis*
Receptors, Histamine H3
Succinimides / metabolism
Reg. No./Substance:
0/Guanidines; 0/Histamine Antagonists; 0/Histamine H1 Antagonists; 0/Histamine H2 Antagonists; 0/Iodine Radioisotopes; 0/Methylhistamines; 0/Receptors, Histamine; 0/Receptors, Histamine H1; 0/Receptors, Histamine H2; 0/Receptors, Histamine H3; 0/Succinimides; 101395-33-9/iodobolpyramine; 126632-01-7/iodoaminopotentidine; 673-50-7/N-methylhistamine; 91-84-9/Pyrilamine

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