| Three generations of alpha,gamma-diaminobutyric acid modified poly(propyleneimine) dendrimers and their cisplatin-type platinum complexes. | |
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MedLine Citation:
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PMID: 16624417 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Three generations of alpha,gamma-diaminobutyric acid modified poly(propyleneimine) dendrimers [DAB(AM)n, n = 4, 8, 16] containing 4, 8, 16 free amino groups were coupled with Boc-protected alpha,gamma-diaminobutyric acid (DABA) moieties in high yields. These modified dendrimers were deprotected and the chiral dendritic amines with 8, 16 and 32 amino groups on the surface were isolated in excellent yields. Dendrimers with cisplatin moieties at the periphery were obtained in the reaction of the free amine dendrimers and potassium tetrachloroplatinate(II). The highly insoluble complexes were isolated as hydrates and characterized by means of IR, TGA and elemental analysis. |
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Authors:
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E Bellis; L Hajba; B Kovács; K Sándor; L Kollár; G Kokotos |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-03-09 |
Journal Detail:
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Title: Journal of biochemical and biophysical methods Volume: 69 ISSN: 0165-022X ISO Abbreviation: J. Biochem. Biophys. Methods Publication Date: 2006 Nov |
Date Detail:
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Created Date: 2006-10-09 Completed Date: 2006-12-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7907378 Medline TA: J Biochem Biophys Methods Country: Netherlands |
Other Details:
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Languages: eng Pagination: 151-61 Citation Subset: IM |
Affiliation:
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University of Athens, Laboratory of Organic Chemistry, 15771 Athens, Greece. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aminobutyric Acids
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chemistry Cisplatin / chemistry* Dendrimers / chemical synthesis, chemistry Magnetic Resonance Spectroscopy Molecular Structure Organoplatinum Compounds / chemical synthesis, chemistry* Polypropylenes / chemical synthesis, chemistry* Spectrometry, Mass, Fast Atom Bombardment Thermogravimetry |
| Chemical | |
Reg. No./Substance:
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0/Aminobutyric Acids; 0/Dendrimers; 0/Organoplatinum Compounds; 0/Polypropylenes; 0/poly(propyleneimine); 15663-27-1/Cisplatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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