| Three-dimensional time-of-flight MR angiography at 3 T compared to digital subtraction angiography in the follow-up of ruptured and coiled intracranial aneurysms: a prospective study. | |
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MedLine Citation:
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PMID: 18196229 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Since digital subtraction angiography (DSA) carries a low risk of morbidity, and is associated with patient discomfort and higher cost, our objective was to determine whether high-resolution 3-D time-of-flight MR angiography (TOF-MRA) at 3 T may replace DSA in the follow-up of patients after coiling of an intracranial aneurysm. METHODS: This prospective study included 50 consecutive patients with a ruptured and subsequently coiled intracranial aneurysm. All patients were followed up at a mean of 14 months after coiling with DSA and high-resolution 3-D TOF-MRA at 3 T generating 0.02 mm3 isotropic voxels. One examiner used DSA and TOF-MR angiograms to assess the need for and risk of retreatment; these data were used to calculate intermodality agreement. Another two examiners independently assessed aneurysm occlusion by DSA and TOF-MRA according to the Raymond scale; these data were used to calculate interobserver agreement. RESULTS: Discrepancies between DSA and TOF-MRA were found in three patients (intermodality agreement kappa=0.86). While DSA indicated complete aneurysm occlusion, TOF-MRA showed small neck remnants in the three patients. Coils on all DSA projections obscured these three neck remnants. Interobserver agreement was higher for DSA (kappa=0.82) than for TOF-MRA (kappa=0.68), which was in part due to the complexity of the information provided by TOF source images and reconstructions. CONCLUSION: 3-D TOF-MRA at 3 T is not only an adjunctive tool but is ready to replace DSA in the follow-up of patients with previously coiled intracranial aneurysms. Additional DSA may only be performed in complex and not clearly laid out aneurysms. |
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Authors:
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H Urbach; U Dorenbeck; M von Falkenhausen; K Wilhelm; W Willinek; C Schaller; S Flacke |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article |
Journal Detail:
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Title: Neuroradiology Volume: 50 ISSN: 0028-3940 ISO Abbreviation: Neuroradiology Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-09-05 Completed Date: 2008-11-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1302751 Medline TA: Neuroradiology Country: Germany |
Other Details:
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Languages: eng Pagination: 383-9 Citation Subset: IM |
Affiliation:
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Department of Radiology, University of Bonn Medical Centre, Bonn, Germany. urbach@uni-bonn.de |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aneurysm, Ruptured / radiography*, therapy Angiography, Digital Subtraction* Child Embolization, Therapeutic Female Follow-Up Studies Humans Imaging, Three-Dimensional* Intracranial Aneurysm / radiography*, therapy Magnetic Resonance Angiography* Male Middle Aged Observer Variation Prospective Studies Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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