Document Detail

Three-dimensional shear-wave elastography for differentiating benign and malignant breast lesions: comparison with two-dimensional shear-wave elastography.
MedLine Citation:
PMID:  23212276     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To evaluate the interobserver agreement and the diagnostic performance of 3D shear-wave elastography (SWE) for breast lesions in comparison with 2D SWE.
METHODS: A total of 163 breast lesions (malignant 48, benign 115) in 146 women who underwent B-mode ultrasound and SWE before biopsy were included. Two radiologists reviewed six data sets (B-mode, SWE, and a combination of both for 2D and 3D ultrasound). B-mode and SWE features were recorded. BI-RADS category was assigned for B-mode and combined sets. Interobserver variability was assessed using the κ statistic. Diagnostic performance of each data set was evaluated using the area under the ROC curve (AUC).
RESULTS: SWE showed substantial to almost perfect agreement, with Ehomo in 2D SWE being higher than in 3D SWE. The AUC of 2D SWE was higher than 3D SWE for all SWE features, significantly so for Ecol (0.933 vs. 0.867, P = 0.002) and Emax (0.961 vs. 0.874, P = 0.006). After adding SWE to B-mode ultrasound, the AUC in 2D ultrasound increased significantly (0.968 vs. 0.912, P = 0.008), but 3D ultrasound showed no significant difference (0.966 vs. 0.935; P = 0.07).
CONCLUSION: For 3D SWE, interobserver agreement was good, but the diagnostic performance was inferior to 2D SWE even after adding to B-mode ultrasound.
KEY POINTS: • Shear-wave elastography (SWE) provides further diagnostic information during breast ultrasound. • 3D SWE diagnostic performance is inferior to 2D SWE. • In 3D SWE, interobserver agreement was good. • 2D B-mode ultrasound showed significant diagnostic improvement when combined with 2D SWE. • 3D B-mode ultrasound performance was not significantly improved when combined with 3D SWE.
Ji Hyun Youk; Hye Mi Gweon; Eun Ju Son; Jin Chung; Jeong-Ah Kim; Eun-Kyung Kim
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-12-02
Journal Detail:
Title:  European radiology     Volume:  23     ISSN:  1432-1084     ISO Abbreviation:  Eur Radiol     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-05-17     Completed Date:  2013-12-26     Revised Date:  2014-08-26    
Medline Journal Info:
Nlm Unique ID:  9114774     Medline TA:  Eur Radiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1519-27     Citation Subset:  IM    
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MeSH Terms
Area Under Curve
Breast / pathology*
Breast Neoplasms / diagnosis*,  pathology*
Diagnosis, Differential
Elasticity Imaging Techniques / methods*
Image Processing, Computer-Assisted
Imaging, Three-Dimensional
Middle Aged
Observer Variation
ROC Curve
Reproducibility of Results
Retrospective Studies
Stress, Mechanical
Ultrasonography, Mammary / methods*
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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