| Three-dimensional reconstruction of the remodeling of the systemic vasculature in early pig embryos. | |
| | |
MedLine Citation:
|
PMID: 17937389 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Current research on angiogenesis and vascular regression is mainly focused on pathological conditions such as tumor growth and diabetic retinopathy, while a suitable physiological model to study the controlling factors in these processes is still lacking. The remodeling pattern of the embryonic vasculature into the adult configuration, such as the branchial arch arterial system developing into the aorta or the early embryonic veins building the caudal vena cava can potentially serve as a model. However, practical applications of the embryonic vascular patterning are impeded by the current controversy over the exact development of the caudal vena cava in mammals. To elucidate these ambiguities, specific developmental stages of vascular development in pig embryos were mapped by means of computer-assisted 3D reconstructions starting from histological serial sections of Bouin's fixed embryos. Special attention was given to venous segments in the lumbar region, as their origin and fate are equivocally described in literature. Here we demonstrate that these venous segments originate from the caudal cardinal veins which are forced to migrate during development into a more dorsal position due to the expansion of the developing metanephroi and the more dorsal relocation of the umbilical arteries. These findings are in contrast with the generally accepted theory that the venous segments in the lumbar region arise from newly formed veins that are located dorsal to the early caudal cardinal system. |
| | |
Authors:
|
Pieter Cornillie; Wim Van Den Broeck; Paul Simoens |
Related Documents
:
|
11963629 - Anomalous veins of the retroperitoneum: clinical considerations. 9066389 - Morphometric study of the right gastroepiploic and inferior epigastric arteries. 8539409 - Guide-wire entrapment by inferior vena caval filters: in vitro evaluation. 11042309 - Doppler and m-mode ultrasonography to time fetal atrial and ventricular contractions. 21070989 - Surgical management of stage iii thymic tumors. 3492099 - Superior vena cava obstruction: a venographic classification. 11584189 - Prognosis in pulmonary embolism. 21170629 - Venous reconstruction with radial artery harvesting: domino method. 12027789 - Aortic arch aneurysm complicated with coronary artery disease: still a surgical challenge? |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Microscopy research and technique Volume: 71 ISSN: 1059-910X ISO Abbreviation: Microsc. Res. Tech. Publication Date: 2008 Feb |
Date Detail:
|
Created Date: 2008-01-21 Completed Date: 2008-04-03 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9203012 Medline TA: Microsc Res Tech Country: United States |
Other Details:
|
Languages: eng Pagination: 105-11 Citation Subset: IM |
Copyright Information:
|
Copyright (c) 2007 Wiley-Liss, Inc. |
Affiliation:
|
Department of Morphology, Faculty of Veterinary Medicine, Ghent University, B-9820 Merelbeke, Belgium. pieter.cornillie@ugent.be |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood Vessels / embryology* Embryo, Mammalian / blood supply* Lumbosacral Region Neovascularization, Physiologic* Swine / embryology* Vena Cava, Inferior / embryology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Characterization of the surface morphology of durum wheat starch granules using atomic force microsc...
Next Document: Preparation of smallest microparticles of poly-D,L-lactide by modified precipitation method: influen...