| Three-dimensional partial zona dissection for preimplantation genetic diagnosis and assisted hatching. | |
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MedLine Citation:
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PMID: 9988403 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To develop a new approach to partial zona dissection of oocytes and embryos for facilitating preimplantation genetic sampling and assisted hatching. DESIGN: Controlled clinical study. SETTING: Preimplantation genetic diagnosis and IVF program, Reproductive Genetics Institute/IVF Illinois, Chicago, Illinois. PATIENT(S): Three hundred forty patients undergoing IVF in whom preimplantation genetic diagnosis or assisted hatching was required. INTERVENTION(S): Three-dimensional partial zona dissection and conventional partial zona dissection were performed, with the use of a simple microneedle, on embryos before preimplantation genetic sampling or on day 3 of embryo development before ET. MAIN OUTCOME MEASURE(S): Pregnancy rate, implantation rate, and ease of preimplantation genetic sampling. RESULT(S): A pregnancy rate of 42% and an embryo implantation rate of 17.6% were obtained in the group in which three-dimensional partial zona dissection was performed, compared with a pregnancy rate of 33% and an implantation rate of 14.7% in the control group, which underwent conventional partial zona dissection. Preimplantation genetic sampling can be performed without distortion of the blastomere configuration in the embryo. CONCLUSION(S): Three-dimensional partial zona dissection is a safe and simple mechanical means of creating an opening sufficient for the atraumatic removal of material from oocytes and embryos for preimplantation genetic diagnosis and assisted hatching. |
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Authors:
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J Cieslak; V Ivakhnenko; G Wolf; S Sheleg; Y Verlinsky |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Fertility and sterility Volume: 71 ISSN: 0015-0282 ISO Abbreviation: Fertil. Steril. Publication Date: 1999 Feb |
Date Detail:
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Created Date: 1999-02-26 Completed Date: 1999-02-26 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 308-13 Citation Subset: IM |
Affiliation:
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Reproductive Genetics Institute, Illinois Masonic Medical Center, Chicago 60657, USA. rgi@flash.net |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Dissection Embryo Implantation Female Fertilization in Vitro* Genetic Testing / methods* Humans Pregnancy Pregnancy Rate Preimplantation Diagnosis / methods* Zona Pellucida* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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