Document Detail

Three-dimensional palpography of human coronary arteries. Ex vivo validation and in-patient evaluation.
MedLine Citation:
PMID:  16493546     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Rupture of thin-cap fibroatheroma is a major cause of acute myocardial infarction and stroke. Identification of these plaques is one of the major challenges in cardiovascular medicine. At present, techniques with sufficient sensitivity and specificity to identify these unstable plaques are not clinically available. This paper describes a new technique to identify these plaques. METHODS AND RESULTS: Three-dimensional intravascular ultrasound palpography is a catheter-based technique that visualizes radial strain (deformation) of vascular tissue induced by physiological variations in intraluminal pressure. A three-dimensional palpogram of these cross sections can be constructed by performing a continuous pullback of the catheter. Phantom and animal experiments revealed feasibility and good reproducibility of three-dimensional palpography. Increased strain values were observed in areas with reduced cap thickness and increased macrophage accumulation. In patients (n = 2) three-dimensional palpography is feasible and identifies areas with high and low strain. CONCLUSION: Three-dimensional palpography allows scanning of coronary arteries in patients to identify and localize highly deformable regions.
Johannes A Schaar; Chris L de Korte; Frits Mastik; Luc C A van Damme; Rob Krams; Patrick W Serruys; Anton F W van der Steen
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Validation Studies    
Journal Detail:
Title:  Herz     Volume:  30     ISSN:  0340-9937     ISO Abbreviation:  Herz     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2006-02-22     Completed Date:  2006-11-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7801231     Medline TA:  Herz     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  125-33     Citation Subset:  IM    
Erasmus University, Rotterdam, The Netherlands.
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MeSH Terms
Coronary Artery Disease / ultrasonography*
Coronary Vessels / ultrasonography*
Image Interpretation, Computer-Assisted / methods*
Imaging, Three-Dimensional / methods*
Palpation / methods
Phantoms, Imaging
Reproducibility of Results
Sensitivity and Specificity
Ultrasonography, Interventional / methods*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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